Rationale and Design of a Randomized Controlled Trial to Evaluate the Effects of Probiotics during Energy Restriction on Blood Pressure, Body Composition, Metabolic Profile and Vascular Function in Obese Hypertensive Individuals

Authors

Marcella Rodrigues Guedes¹, Karine Scanci da Silva Pontes¹, Débora Cristina Torres Valença¹, Wille Oigman², Mario Fritsch Neves^2, , Márcia Regina Simas Torres Klein^{3, *,}

¹Discipline of Clinical and Experimental Pathophysiology, State University of Rio de Janeiro, Avenida Vinte e Oito de Setembro, 77 – rooms 361 and 363, Vila Isabel, Rio de Janeiro, RJ, Brazil

²Department of Clinical Medicine, State University of Rio de Janeiro, Avenida Vinte e Oito de Setembro, 77, room 329, Vila Isabel, Rio de Janeiro, RJ, Brazil

³Department of Applied Nutrition, Nutrition Institute, State University of Rio de Janeiro, Avenida Vinte e Oito de Setembro, 77 – rooms 361 and 363, Vila Isabel, Rio de Janeiro, RJ, Brazil

^*Corresponding author. Email: marciarsimas@gmail.com

DOI

10.2991/artres.k.200429.001How to use a DOI?

Keywords

Hypertension; obesity; probiotics; metabolic profile; vascular function

Abstract

Introduction: Hypertension often clusters with other cardiovascular risk factors such as obesity, dyslipidemia and glucose intolerance. Weight loss can decrease Blood Pressure (BP) and improve cardiometabolic abnormalities. There is evidence that hypertension and obesity are associated with alterations in gut microbiome. Recent studies evaluating the effects of probiotics on BP, body weight, metabolic profile, inflammatory biomarkers, endothelial function and arterial stiffness found inconsistent results, probably due to the wide heterogeneity in trials design. To date, it is not known if probiotics can potentiate the effects of energy restriction in individuals with increased risk of metabolic, inflammatory and vascular abnormalities such as individuals presenting hypertension and obesity.

Objective: To evaluate the effects of probiotics during energy restriction on BP, body adiposity (total, central and visceral), insulin resistance, lipid profile, microvascular reactivity and arterial stiffness in obese hypertensive subjects.

Methods: This 12-week randomized, double-blind, controlled clinical trial with obese hypertensive adults, instructed to follow an energy-reduced diet (−800 Kcal/day) will be conducted at State University of Rio de Janeiro, Brazil. Probiotics and control groups will take one capsule/day containing nine freeze-dried probiotic strains and cellulose, respectively. At baseline and at the end of the study, participants will undergo nutritional, laboratory, BP and vascular evaluation. Nutritional assessment will include bioelectrical impedance analysis and dual energy X-ray absorptiometry. Laboratory parameters will include glucose, insulin, lipid profile, C-reactive protein, adiponectin, tumor necrosis factor alpha, interleukin-6 and lipopolysaccharide. Post-occlusive microvascular reactivity will be evaluated by laser speckle contrast imaging and oscillometric pulse wave analysis by Mobil-O-Graph.

Copyright

© 2020 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.

Open Access

This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - JOUR
AU  - Marcella Rodrigues Guedes
AU  - Karine Scanci da Silva Pontes
AU  - Débora Cristina Torres Valença
AU  - Wille Oigman
AU  - Mario Fritsch Neves
AU  - Márcia Regina Simas Torres Klein
PY  - 2020
DA  - 2020/05/02
TI  - Rationale and Design of a Randomized Controlled Trial to Evaluate the Effects of Probiotics during Energy Restriction on Blood Pressure, Body Composition, Metabolic Profile and Vascular Function in Obese Hypertensive Individuals
JO  - Artery Research
SP  - 102
EP  - 110
VL  - 26
IS  - 2
SN  - 1876-4401
UR  - https://doi.org/10.2991/artres.k.200429.001
DO  - 10.2991/artres.k.200429.001
ID  - Guedes2020
ER  -