Artery Research

Volume 24, Issue C, December 2018, Pages 103 - 104

P87 CEREBROVASCULAR REACTIVITY DURING COGNITIVE ACTIVATION IN ADULTS WITH CONTROLLED HYPERTENSION

Authors
Wesley Lefferts1, Jacob DeBlois2, Tiago Barreira2, Kevin Heffernan2
1University of Illinois at Chicago, USA
2Syracuse University, USA
Available Online 4 December 2018.
DOI
10.1016/j.artres.2018.10.140How to use a DOI?
Abstract

Hypertension, even when pharmaceutically controlled, may accelerate arterial stiffening and impair changes in blood flow necessary to support neural activity (neurovascular coupling [NVC]). Optimal NVC requires continuous, non-pulsatile flow, which is partially determined by extra- and intra-cranial vessel function.

Purpose: Examine extra- and intra-cranial hemodynamics during cognitive activity in adults with well-controlled hypertension and without hypertension.

Methods: 30 middle-aged, medicated hypertensive and 30 age-, sex-, and Body Mass Index (BMI)-matched non-hypertensive adults (56 ± 6 yrs, BMI 28.2 ± 2.9 kg/m2; 32 men) underwent cerebrovascular measures at rest and during a Stroop task. Applanation tonometry and ultrasound were used to assess aortic and carotid (single-point) Pulse Wave Velocity (PWV), respectively. Ultrasound and Doppler were used to measure carotid and Middle Cerebral Artery (MCA) blood velocity pulsatility. Near-infrared spectroscopy was used to measure prefrontal oxygenation (tissue saturation index; TSI). Accuracy and reaction times were computed to assess cognitive performance.

Results: Stroop performance was similar between groups (p > 0.01). Aortic and carotid PWV increased, carotid pulsatility decreased (p0.01; Table 1). Reductions in CCA pulsatility during the Stroop were associated with increases in cortical TSI in the combined sample (r = 0.27), suggesting extracranial hemodynamics may play a role in optimizing intracranial NVC.

Conclusions: Our findings indicate that middle-age adults with medically-controlled hypertension display similar intra- and extra-cranial cerebrovascular reactivity to adults without hypertension. Additionally, adults with and without hypertension may utilize reductions in extracranial pulsatility during NVC to minimize intracranial pulsatility and improve downstream cerebral oxygenation.

Open Access
This is an open access article distributed under the CC BY-NC license.

Journal
Artery Research
Volume-Issue
24 - C
Pages
103 - 104
Publication Date
2018/12/04
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2018.10.140How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - Wesley Lefferts
AU  - Jacob DeBlois
AU  - Tiago Barreira
AU  - Kevin Heffernan
PY  - 2018
DA  - 2018/12/04
TI  - P87 CEREBROVASCULAR REACTIVITY DURING COGNITIVE ACTIVATION IN ADULTS WITH CONTROLLED HYPERTENSION
JO  - Artery Research
SP  - 103
EP  - 104
VL  - 24
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2018.10.140
DO  - 10.1016/j.artres.2018.10.140
ID  - Lefferts2018
ER  -