Artery Research

Volume 7, Issue 3-4, September 2013, Pages 140 - 141

P4.19 THE EFFECT OF AN 8-WEEK, MODERATE-INTENSITY, AEROBIC EXERCISE INTERVENTION ON MMP-9 AND VASCULAR HAEMODYNAMICS

Authors
J.E.S. Thompson1, R. Webb1, P. Hewlett1, D. Llewellyn2, B.J. McDonnell1
1Cardiff School of Health Sciences, Cardiff Metropolitan University, Cardiff, United Kingdom
2Groundwork Wales, Treforest, United Kingdom
Available Online 11 November 2013.
DOI
10.1016/j.artres.2013.10.137How to use a DOI?
Abstract

Objective: The Matrix Metalloproteinase-9 (MMP-9) enzyme is involved in degrading extracellular matrix (ECM) proteins, including collagen and elastin. Increased MMP-9 levels are associated with increased vascular remodelling and arterial stiffness. Exercise improves age-related vascular stiffening. It is therefore hypothesised that participation in an aerobic, moderate-intensity exercise programme will down-regulate mRNA expression of MMP-9.

Methods: Thirty-six healthy, sedentary individuals (43±14 yrs) joining an aerobic, moderate-intensity exercise programme, were recruited. Exercise (measured using IPAQ MET-minutes), supine blood pressure, augmentation index (AIx), aortic-pulse wave velocity (aPWV) and blood samples were obtained at baseline and 8-weeks into the programme. MMP-9 mRNA expression was analysed using real-time PCR, circulating MMP-9 levels assessed via ELISA, and AIx and aPWV were measured via applanation tonometry (SphygmoCor). Participants were split into those who adhered and did not adhere to the exercise programme.

Results: MET-minutes significantly increased; whilst MMP-9 expression, MAP and AIx significantly decreased in the exercise-adherent group compared to the non-adherent group, between baseline and 8-weeks. aPWV did not change significantly between the groups (Table-1). Significant correlations were observed between ΔIPAQ MET-minutes and ΔMMP-9 expression.

Conclusion: Adherence to the exercise programme reduced wave reflection and MAP. These pilot data demonstrate that MMP-9 expression is down-regulated in healthy, sedentary adults after 8-weeks of aerobic, moderate-intensity exercise. Thus suggesting that exercise-induced down-regulation of MMP-9 may result in a reduction in ECM degradation and therefore reduce vascular remodelling. These data provide a biomolecular rationale for how aerobic exercise is effective at delaying age-related increases in aPWV.

Parameter Adherent n=17 (Mean±SE) Non-Adherent n=19 (Mean±SE) P Value
Δ IPAQ (MET-minutes) +2848 ±547 −404 ±267 <0.001
Δ MMP-9 (Ct) −0.56 ±0.09 +0.42 ±0.44 0.034
Δ Supine MAP (mmHg) −2.64 ±1.59 +1.45 ±1.16 0.044
Δ Supine AIx@75 (%) −4.1 ±1.75 +1.9 ±2.23 0.045
Δ CF-PWV (m/s) +0.3 ±0.2 +0.2 ±0.2 0.854
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Journal
Artery Research
Volume-Issue
7 - 3-4
Pages
140 - 141
Publication Date
2013/11/11
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2013.10.137How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - J.E.S. Thompson
AU  - R. Webb
AU  - P. Hewlett
AU  - D. Llewellyn
AU  - B.J. McDonnell
PY  - 2013
DA  - 2013/11/11
TI  - P4.19 THE EFFECT OF AN 8-WEEK, MODERATE-INTENSITY, AEROBIC EXERCISE INTERVENTION ON MMP-9 AND VASCULAR HAEMODYNAMICS
JO  - Artery Research
SP  - 140
EP  - 141
VL  - 7
IS  - 3-4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2013.10.137
DO  - 10.1016/j.artres.2013.10.137
ID  - Thompson2013
ER  -