Artery Research

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Volume 4, Issue 4, December 2010, Pages 114 - 117

Interrelationships between macro and microvascular structure and function

Authors
Damiano Rizzoni*, Maria Lorenza Muiesan, Enzo Porteri, Carolina De Ciuceis, Gianluca E.M. Boari, Massimo Salvetti, Anna Paini, Enrico Agabiti Rosei
Clinica Medica, Department of Medical and Surgical Sciences, University of Brescia, c/o 2aMedicina, Spedali Civili, 25100 Brescia, Italy
*Corresponding author. Tel.: +39 030 3995815; fax: +39 030 3384348. E-mail address: rizzoni@med.unibs.it (D. Rizzoni).
Corresponding Author
Damiano Rizzoni
Available Online 29 October 2010.
DOI
10.1016/j.artres.2010.10.001How to use a DOI?
Keywords
Antihypertensive therapy; Macrocirculation; Microcirculation
Abstract

Macrovasculature and microvasculature are interrelated, and may influence each other. Microvascular structure is not only the site of vascular resistance but probably also the origin of most of the wave reflections generating increased central systolic blood pressure. Some index of large artery stiffness seems to be related with the media to lumen ratio of subcutaneous small resistance arteries of hypertensive patients. In addition, both microvascular structural alterations and changes in the mechanical properties of large arteries represent potent predictors of prognosis. In addition, drugs that may improve microvascular structure may also correct alterations in the mechanical properties of large arteries In fact, while β-blocking agents and diuretics have a negligible effect on microvascular structure, renin-angiotensin system antagonists and calcium entry blockers have favorable actions, improving also large artery mechanics and possibly reducing central wave reflections.

Copyright
© 2010 Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved.
Open Access
This is an open access article distributed under the CC BY-NC license.

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<Previous Article In Issue
Next Article In Issue>
Journal
Artery Research
Volume-Issue
4 - 4
Pages
114 - 117
Publication Date
2010/10/29
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2010.10.001How to use a DOI?
Copyright
© 2010 Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved.
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Damiano Rizzoni
AU  - Maria Lorenza Muiesan
AU  - Enzo Porteri
AU  - Carolina De Ciuceis
AU  - Gianluca E.M. Boari
AU  - Massimo Salvetti
AU  - Anna Paini
AU  - Enrico Agabiti Rosei
PY  - 2010
DA  - 2010/10/29
TI  - Interrelationships between macro and microvascular structure and function
JO  - Artery Research
SP  - 114
EP  - 117
VL  - 4
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2010.10.001
DO  - 10.1016/j.artres.2010.10.001
ID  - Rizzoni2010
ER  -