Study on synthesis of (2S,3S)-2-methyl-3-((triethylsilyl)oxy)pentanal

DOI

10.2991/mmeceb-15.2016.159How to use a DOI?

Keywords

(2S,3S)-2-methyl-3-((triethylsilyl)oxy)pentanal, actinoallolide A, Evans aldol, L-Phenylalanine, synthesis.

Abstract

The C19-C23 fragment (9) of the anti-trypanosomal natural product actinoallolide A was prepared via an elegant stereo-controlled route. We installed the chiral center at C20 through a standard Evans aldol reaction, and protected the secondary hydroxyl group via a silylanization.

Copyright

© 2016, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Shenkun Yang
AU  - TianXiang Xu
AU  - Shuangping Huang
AU  - Xiaoji Wang
PY  - 2015/12
DA  - 2015/12
TI  - Study on synthesis of (2S,3S)-2-methyl-3-((triethylsilyl)oxy)pentanal
BT  - Proceedings of the 2015 2nd International Conference on Machinery, Materials Engineering, Chemical Engineering and Biotechnology
PB  - Atlantis Press
SP  - 802
EP  - 805
SN  - 2352-5401
UR  - https://doi.org/10.2991/mmeceb-15.2016.159
DO  - 10.2991/mmeceb-15.2016.159
ID  - Yang2015/12
ER  -