Proceedings of the 2015 2nd International Conference on Machinery, Materials Engineering, Chemical Engineering and Biotechnology

Study on Synthesis of (R)-tert-butyl 2,2-dimethyl-4-(prop-1-yn-1-yl)oxazo lidine-3-carboxylate

Authors
Cheng Liang, ShuangLin Qin, Xiaoji Wang, Shuangping Huang
Corresponding Author
Cheng Liang
Available Online December 2015.
DOI
10.2991/mmeceb-15.2016.160How to use a DOI?
Keywords
(R)-tert-butyl 2,2-dimethyl-4-(prop-1-yn-1-yl)oxazolidine-3-carboxylate, Biotin, L-serine, synthesis
Abstract

(R)-tert-butyl 2,2-dimethyl-4-(prop-1-yn-1-yl)oxazolidine-3-carboxylate, an key intermediate of Biotin which is a water-soluble vitamin involved in an essential part of the metabolic cyle causing catalytic fixation of carbon dioxide in the biosynthesis of fatty acids, sugars, and -amino acids, was synthesized from L-cystine in overall yield 41% through six steps, which included esterification, Boc protection, acetonization, reduction, Corey-Fuchs reaction.

Copyright
© 2016, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Download article (PDF)

Volume Title
Proceedings of the 2015 2nd International Conference on Machinery, Materials Engineering, Chemical Engineering and Biotechnology
Series
Advances in Engineering Research
Publication Date
December 2015
ISBN
978-94-6252-151-3
ISSN
2352-5401
DOI
10.2991/mmeceb-15.2016.160How to use a DOI?
Copyright
© 2016, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

TY  - CONF
AU  - Cheng Liang
AU  - ShuangLin Qin
AU  - Xiaoji Wang
AU  - Shuangping Huang
PY  - 2015/12
DA  - 2015/12
TI  - Study on Synthesis of (R)-tert-butyl 2,2-dimethyl-4-(prop-1-yn-1-yl)oxazo lidine-3-carboxylate
BT  - Proceedings of the 2015 2nd International Conference on Machinery, Materials Engineering, Chemical Engineering and Biotechnology
PB  - Atlantis Press
SP  - 806
EP  - 809
SN  - 2352-5401
UR  - https://doi.org/10.2991/mmeceb-15.2016.160
DO  - 10.2991/mmeceb-15.2016.160
ID  - Liang2015/12
ER  -