Study on Synthesis of (R)-tert-butyl 2,2-dimethyl-4-(prop-1-yn-1-yl)oxazo lidine-3-carboxylate

DOI

10.2991/mmeceb-15.2016.160How to use a DOI?

Keywords

(R)-tert-butyl 2,2-dimethyl-4-(prop-1-yn-1-yl)oxazolidine-3-carboxylate, Biotin, L-serine, synthesis

Abstract

(R)-tert-butyl 2,2-dimethyl-4-(prop-1-yn-1-yl)oxazolidine-3-carboxylate, an key intermediate of Biotin which is a water-soluble vitamin involved in an essential part of the metabolic cyle causing catalytic fixation of carbon dioxide in the biosynthesis of fatty acids, sugars, and -amino acids, was synthesized from L-cystine in overall yield 41% through six steps, which included esterification, Boc protection, acetonization, reduction, Corey-Fuchs reaction.

Copyright

© 2016, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Cheng Liang
AU  - ShuangLin Qin
AU  - Xiaoji Wang
AU  - Shuangping Huang
PY  - 2015/12
DA  - 2015/12
TI  - Study on Synthesis of (R)-tert-butyl 2,2-dimethyl-4-(prop-1-yn-1-yl)oxazo lidine-3-carboxylate
BT  - Proceedings of the 2015 2nd International Conference on Machinery, Materials Engineering, Chemical Engineering and Biotechnology
PB  - Atlantis Press
SP  - 806
EP  - 809
SN  - 2352-5401
UR  - https://doi.org/10.2991/mmeceb-15.2016.160
DO  - 10.2991/mmeceb-15.2016.160
ID  - Liang2015/12
ER  -