Synthesis of N-4-(4-chloro-3-trifluoromethyl-phenyl)-7-methoxy-quinazoline-4,6-diamine

DOI

10.2991/mmeceb-15.2016.158How to use a DOI?

Keywords

N-4-(4-chloro-3-trifluoromethyl-phenyl)-7-methoxy-quinazoline-4,6-diamine, 4-chloro-7-fluoro-6-nitro-quinazoline, Synthesis

Abstract

N-4-(4-chloro-3-trifluoromethyl-phenyl)-7-methoxy-quinazoline-4,6-diamine (1) exhibited potential biological activities in medicine, 4-chloro-7-fluoro-6-nitro-quinazoline (2) is an important intermediate in compound 1. In this work, a rapid synthetic method for compound 1 was established. The compound 1 was synthesized from the commercially available 4-chloro-7-fluoro-6-nitro-quinazoline 2 through three steps including substitution with phenylamine, nucleophilic substitution reaction and reduction reaction. The structures were confirmed by 1HNMR. Furthermore, the synthetic method was optimized.

Copyright

© 2016, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Yiqiang OuYang
AU  - Chen Chen
AU  - Ping Wang
AU  - Chao Sun
AU  - WuFu Zhu
AU  - Shan Xu
PY  - 2015/12
DA  - 2015/12
TI  - Synthesis of N-4-(4-chloro-3-trifluoromethyl-phenyl)-7-methoxy-quinazoline-4,6-diamine
BT  - Proceedings of the 2015 2nd International Conference on Machinery, Materials Engineering, Chemical Engineering and Biotechnology
PB  - Atlantis Press
SP  - 798
EP  - 801
SN  - 2352-5401
UR  - https://doi.org/10.2991/mmeceb-15.2016.158
DO  - 10.2991/mmeceb-15.2016.158
ID  - OuYang2015/12
ER  -