Synthesis of 3-bromo-4-isobutyloxyphenyl carbothioamide

DOI

10.2991/mmeceb-15.2016.157How to use a DOI?

Keywords

3-bromo-4-isobutyloxyphenyl carbothioamide, Synthesis

Abstract

3-bromo-4-isobutyloxyphenyl carbothioamide 1 is an important intermediate in many biologically active compounds such as febuxostat. In this work, a rapid synthetic method for compound 1 was established. The compound 1 was synthesized from the commercially available 4-hydroxybenzonitrile 2 through three steps including bromination, oxyalkylation and thioamidation. The structure was confirmed by MS and 1HNMR. Furthermore, the synthetic method was optimized. The total yield of the three steps was 49.2%.

Copyright

© 2016, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Qinqin Wang
AU  - Yuping Guo
AU  - Min Wang
AU  - WuFu Zhu
AU  - Shan Xu
PY  - 2015/12
DA  - 2015/12
TI  - Synthesis of 3-bromo-4-isobutyloxyphenyl carbothioamide
BT  - Proceedings of the 2015 2nd International Conference on Machinery, Materials Engineering, Chemical Engineering and Biotechnology
PB  - Atlantis Press
SP  - 794
EP  - 797
SN  - 2352-5401
UR  - https://doi.org/10.2991/mmeceb-15.2016.157
DO  - 10.2991/mmeceb-15.2016.157
ID  - Wang2015/12
ER  -