Proceedings of the Health Science International Conference (HSIC 2017)

In vivo Antiplasmodial Activity of (E) 1 - (4 - aminophenyll) - 3 - (2,3 - dimethoxyphenyl) prop - 2 - en - 1 - one compound in Swiss Mice

Authors
Lilik Wijayanti, Mustofa Mustofa, Purwanto Purwanto, Muthmainah Muthmainah, Suwito Suwito
Corresponding Author
Lilik Wijayanti
Available Online October 2017.
DOI
https://doi.org/10.2991/hsic-17.2017.66How to use a DOI?
Keywords
Anti-plasmodium; ED50; (E) - 1 - (4 - aminophenyll) - 3 - (2,3 - dimethoxyphenyl) prop - 2 - en - 1 - one
Abstract

Malaria is an infectious disease caused by plasmodium sp. Resistance to antimalarial drug urges the finding of new antimalarial agents. One of the potential agents is a chalcone derivate namely (E) - 1 - (4 - aminophenyll) - 3 - (2,3 - dimethoxyphenyl) prop - 2 - en - 1 - one. Objective : This study aimed to test the effect of (E) - 1 - (4 - aminophenyll) - 3 - (2,3 - dimethoxyphenyl) prop - 2 - en - 1 - one on plasmodium sp infection in vivo by measuring the median effective dose (ED 50). Methods : Swiss mice were divided into 6 groups consisting of control group and treatment groups receiving various doses of tested compound (10 mg, 20 mg, 40 mg, 80 mg and 160 mg /BW/day respectively). Tested compound were given for 7 consecutive days. Malaria model was made by infecting mice with 106 P. Berghei on day 4. Parasitemia were measured on day 5 after infection. ED50 was counted with probit analysis. Result : Probit analysis showed that the ED50 value for (E) - 1 - (4 - aminophenyll) - 3 - (2,3 - dimethoxyphenyl) prop - 2 - en - 1 - one was 17,36 mg / BW. Conclusion : (E) - 1 - (4 - aminophenyll) - 3 - (2,3 - dimethoxyphenyl) prop - 2 - en - 1 - one has a very good anti-plasmodial property

Copyright
© 2017, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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Volume Title
Proceedings of the Health Science International Conference (HSIC 2017)
Series
Advances in Health Sciences Research
Publication Date
October 2017
ISBN
978-94-6252-413-2
ISSN
2468-5739
DOI
https://doi.org/10.2991/hsic-17.2017.66How to use a DOI?
Copyright
© 2017, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

TY  - CONF
AU  - Lilik Wijayanti
AU  - Mustofa Mustofa
AU  - Purwanto Purwanto
AU  - Muthmainah Muthmainah
AU  - Suwito Suwito
PY  - 2017/10
DA  - 2017/10
TI  - In vivo Antiplasmodial Activity of (E) 1 - (4 - aminophenyll) - 3 - (2,3 - dimethoxyphenyl) prop - 2 - en - 1 - one compound in Swiss Mice
BT  - Proceedings of the Health Science International Conference (HSIC 2017)
PB  - Atlantis Press
SP  - 427
EP  - 430
SN  - 2468-5739
UR  - https://doi.org/10.2991/hsic-17.2017.66
DO  - https://doi.org/10.2991/hsic-17.2017.66
ID  - Wijayanti2017/10
ER  -