Proceedings of the Health Science International Conference (HSIC 2017)

Chlorogenic Acid Attenuated Inflammatory Response in Kidney Disease with Ischemic Reperfusion Injury

Authors
Ali Multazam, Sri Rini
Corresponding Author
Ali Multazam
Available Online October 2017.
DOI
https://doi.org/10.2991/hsic-17.2017.2How to use a DOI?
Keywords
acute kidney injury, chlorogenic acid, inflammation, leukocyte
Abstract

Ischemia reperfusion injury (I/R) at kidney has known as the primary cause of AKI and the most seeing through it. Chlorogenic acid (chlorogenic acid/CGA) is one of the most common polyphenols in the human diet. Chlorogenic acid has an antioxidant effect, antiapoptosis, antiinflammation, antifobrosis. Objective: To investigate the anti-inflammatory effect of chlorogenic acid on the kidneys with I/R injury. Methods: Twenty male mice (3 months-old). The animals were divided into 4 groups, Ischemia reperfusion (IR, n = 5), I/R injury given CGA dose 3.5 mg/kg/BW (IRCGA1, n = 5), I/R injury given CGA dose of 7 mg/kg/BW (IRCGA2, n = 5), and I/R injury given CGA dose 14 mg/kg/BW (IRCGA3, n = 5). The CGA was given intraperitoneally injection for 3 days. At the end of the examination, serum creatinine and leukocytes levels were taken from retroorbital venous blood. The data were analyzed by one-way ANOVA and Kruskal-Wallis statistic test (p <0.05). Results and Conclusion: The IRCGA3 group showed an increase of creatinin serum and leukocytes level compared to the IR group (p <0.05). Chlorogenic acid is known antioxidant and anti-inflammatory can inhibit the inflammatory response

Copyright
© 2017, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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Volume Title
Proceedings of the Health Science International Conference (HSIC 2017)
Series
Advances in Health Sciences Research
Publication Date
October 2017
ISBN
978-94-6252-413-2
ISSN
2468-5739
DOI
https://doi.org/10.2991/hsic-17.2017.2How to use a DOI?
Copyright
© 2017, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

TY  - CONF
AU  - Ali Multazam
AU  - Sri Rini
PY  - 2017/10
DA  - 2017/10
TI  - Chlorogenic Acid Attenuated Inflammatory Response in Kidney Disease with Ischemic Reperfusion Injury
BT  - Proceedings of the Health Science International Conference (HSIC 2017)
PB  - Atlantis Press
SP  - 7
EP  - 11
SN  - 2468-5739
UR  - https://doi.org/10.2991/hsic-17.2017.2
DO  - https://doi.org/10.2991/hsic-17.2017.2
ID  - Multazam2017/10
ER  -