Proceedings of the 2015 International Conference on Education, Management, Information and Medicine

Synthesis of 5-(4-Morpholino-7, 8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-2-yl)pyridin-2-amine

Authors
Ping Wang, Chengyu Sun, Yueyue Xiao, Chen Chen, Zhenhua Chen, Wufu Zhu
Corresponding Author
Ping Wang
Available Online April 2015.
DOI
10.2991/emim-15.2015.168How to use a DOI?
Keywords
Thiopyrano[4;3-d]pyrimidine; Morpholine; Synthesis; Anticancer; Inhibitors
Abstract

A novel thiopyrano[4,3-d]pyrimidine derivative compound 1 was synthesized with methyl dimethyl 3,3'-thiodipropionate as starting material through five steps, including cyclization, chlorination, substitution with morpholine and coupling with 5-bromopyridin-2-amine through Suzuki reaction. And its structure was confirmed by 1H NMR and MS. The total yield of the five steps was 18.6% (calculated from methyl dimethyl 3,3'-thiodipropionate).Compound 1 is an important intermediate in the design and synthesis of thiopyrano[4,3-d]pyrimidine derivatives small molecule inhibitors.Therefore, the synthesis of Compound 1 has an important significance in the the study of anticancer drugs.

Copyright
© 2015, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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Volume Title
Proceedings of the 2015 International Conference on Education, Management, Information and Medicine
Series
Advances in Economics, Business and Management Research
Publication Date
April 2015
ISBN
10.2991/emim-15.2015.168
ISSN
2352-5428
DOI
10.2991/emim-15.2015.168How to use a DOI?
Copyright
© 2015, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

TY  - CONF
AU  - Ping Wang
AU  - Chengyu Sun
AU  - Yueyue Xiao
AU  - Chen Chen
AU  - Zhenhua Chen
AU  - Wufu Zhu
PY  - 2015/04
DA  - 2015/04
TI  - Synthesis of 5-(4-Morpholino-7, 8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-2-yl)pyridin-2-amine
BT  - Proceedings of the 2015 International Conference on Education, Management, Information and Medicine
PB  - Atlantis Press
SP  - 863
EP  - 866
SN  - 2352-5428
UR  - https://doi.org/10.2991/emim-15.2015.168
DO  - 10.2991/emim-15.2015.168
ID  - Wang2015/04
ER  -