Synthesis and Anticancer Activity Of One Novel Thiopyrano[4,3-D]Pyrimidine Derivative Bearing A Indole-hydrazone
Authors
Chengyu Sun, Chen Chen, Shan Xu, Qingqing Hu, Pengwu Zheng, Wufu Zhu
Corresponding Author
Chengyu Sun
Available Online April 2015.
- DOI
- 10.2991/emim-15.2015.167How to use a DOI?
- Keywords
- Thiopyrano[4;3-D]pyrimidine; Synthesis; mTOR Inhibitors; Indole-hydrazone; Anticancer.
- Abstract
A novel thiopyrano[4,3-d]pyrimidin derivative bearing a indole-hydrazone was synthesized and structure was confirmed by 1H NMR and MS. Moreover, this compound was evaluated for its cytotoxicity against the H460 cell lines and inhibitory activity against mTOR kinase at a concentration of 10uM. The result indicated that this compound exhibited moderate activity against cancer cell line as well as mTOR kinase. At 10 M level, the inhibition rate of compound 1 against H460 cell lines and mTOR kinase was 39.6% and 47.0%.
- Copyright
- © 2015, the Authors. Published by Atlantis Press.
- Open Access
- This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).
Cite this article
TY - CONF AU - Chengyu Sun AU - Chen Chen AU - Shan Xu AU - Qingqing Hu AU - Pengwu Zheng AU - Wufu Zhu PY - 2015/04 DA - 2015/04 TI - Synthesis and Anticancer Activity Of One Novel Thiopyrano[4,3-D]Pyrimidine Derivative Bearing A Indole-hydrazone BT - Proceedings of the 2015 International Conference on Education, Management, Information and Medicine PB - Atlantis Press SP - 859 EP - 862 SN - 2352-5428 UR - https://doi.org/10.2991/emim-15.2015.167 DO - 10.2991/emim-15.2015.167 ID - Sun2015/04 ER -