Morphological Characteristics of Drug-loaded Nanoparticles based on Microscope Images Analysis System

DOI

10.2991/citcs.2012.178How to use a DOI?

Keywords

component; Nanoparticle; Microscope Image Analysis; Morphological Characteristics

Abstract

Microscope images analysis of drug carriers was a widely used method for those nanomaterials. Usually manual measuring and analysis of microscope images were subject to errors, and bad stability of results. Nanoparticles microscope images analysis method was combined with computer image processing technique in this research. A new nanoparticle Rot/CMC-g-RA was prepared with chitosan derivate drug carrier CMC-g-RA and botanical drug rotenone (Rot), and a processing and measuring system for microscope images of those drug-loaded nanoparticles was prepared by Visual C++ 6.0. The result showed characteristics measured by the system such as nanoparticles, particle size, area and roundness of Rot/CMC-g- RA were close to that measured by dynamic light scattering (DLS) method. And a fast, precise and automatic method for measuring and statistic nanoparticles morphometric parameters was developed.

Copyright

© 2012, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Bohua Feng
AU  - Siyuan Mo
AU  - Liufen Peng
AU  - Huoyan Xu
PY  - 2012/11
DA  - 2012/11
TI  - Morphological Characteristics of Drug-loaded Nanoparticles based on Microscope Images Analysis System
BT  - Proceedings of the 2012 National Conference on Information Technology and Computer Science
PB  - Atlantis Press
SP  - 698
EP  - 701
SN  - 1951-6851
UR  - https://doi.org/10.2991/citcs.2012.178
DO  - 10.2991/citcs.2012.178
ID  - Feng2012/11
ER  -