First and second line drug resistance among treatment naïve pulmonary tuberculosis patients in a district under Revised National Tuberculosis Control Programme (RNTCP) in New Delhi

Vithal Prasad Myneedu; Ritu Singhal; Khalid Umer Khayyam; Prem Prakash Sharma; Manpreet Bhalla; Digamber Behera; Rohit Sarin

doi:10.1016/j.jegh.2015.04.002

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Volume 5, Issue 4, December 2015, Pages 365 - 373

First and second line drug resistance among treatment naïve pulmonary tuberculosis patients in a district under Revised National Tuberculosis Control Programme (RNTCP) in New Delhi

Authors

Vithal Prasad Myneedu^a^{, *}^,tbmicro@gmail.com, Ritu Singhal^a^,ritugo@hotmail.com, Khalid Umer Khayyam^b^,dr.khaliduk@yahoo.com, Prem Prakash Sharma^c^,ppsharma@hotmail.com, Manpreet Bhalla^a^,mnprtbhalla@yahoo.com, Digamber Behera^d^,dirlrsi@gmail.com, Rohit Sarin^e^,tbmicro@gmail.com

^aNational Reference Laboratory & WHO Center of Excellence (Tuberculosis), Department of Microbiology, National Institute of Tuberculosis and Respiratory Diseases, New Delhi 110030, India

^bDepartment of Epidemiology, National Institute of Tuberculosis and Respiratory Diseases, New Delhi 110030, India

^cDepartment of Statistics, National Institute of Tuberculosis and Respiratory Diseases, New Delhi 110030, India

^dDepartment of Pulmonary Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh 160012, India

^eDepartment of Tuberculosis and Chest Diseases, National Institute of Tuberculosis and Respiratory Diseases, New Delhi 110030, India

^*Corresponding author at: National Reference Laboratory & WHO Center of Excellence (Tuberculosis), Department of Microbiology, National Institute of Tuberculosis & Respiratory Diseases (NITRD), New Delhi 110030, India. Tel.: +91 26854929, +91 26517826, +91 26854922, +91 126517830, +91 26855094.

Corresponding Author

Vithal Prasad Myneedutbmicro@gmail.com

Received 10 February 2015, Revised 4 April 2015, Accepted 6 April 2015, Available Online 2 May 2015.

DOI: 10.1016/j.jegh.2015.04.002 How to use a DOI?
Keywords: Antibiotic; Primary; Pulmonary; Multi-drug resistance; Extensively drug resistance
Abstract: There is limited information of level of drug resistance to first-line and second line anti-tuberculosis agents in treatment naïve pulmonary tuberculosis (PTB) patients from the Indian region. Therefore, the present prospective study was conducted to determine the antimicrobial susceptibility to first-line and second line anti-TB drug resistance in such patients. Sputum samples from consecutive treatment naïve PTB cases registered in Lala Ram Sarup (LRS) district, under RNTCP containing 12 Directly Observed Treatment Centre’s (DOTS), were enrolled using cluster sampling technology. A total of 453 samples were received from July 2011 to June 2012. All samples were cultured on solid medium followed by drug susceptibility to first and second line anti-tubercular drugs as per RNTCP guidelines. Primary multi-drug resistance (MDR) was found to be 18/453; (4.0%). Extensively drug resistance (XDR) was found in one strain (0.2%), which was found to be resistant to other antibiotics. Data of drug resistant tuberculosis among treatment naïve TB patients are lacking in India. The presence of XDR-TB and high MDR-TB in small population studied, calls for conducting systematic multi-centric surveillance across the country.
Open Access: This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Journal: Journal of Epidemiology and Global Health
Volume-Issue: 5 - 4
Pages: 365 - 373
Publication Date: 2015/05/02
ISSN (Online): 2210-6014
ISSN (Print): 2210-6006
DOI: 10.1016/j.jegh.2015.04.002 How to use a DOI?
Open Access: This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Cite this article

ris enw bib

TY  - JOUR
AU  - Vithal Prasad Myneedu
AU  - Ritu Singhal
AU  - Khalid Umer Khayyam
AU  - Prem Prakash Sharma
AU  - Manpreet Bhalla
AU  - Digamber Behera
AU  - Rohit Sarin
PY  - 2015
DA  - 2015/05/02
TI  - First and second line drug resistance among treatment naïve pulmonary tuberculosis patients in a district under Revised National Tuberculosis Control Programme (RNTCP) in New Delhi
JO  - Journal of Epidemiology and Global Health
SP  - 365
EP  - 373
VL  - 5
IS  - 4
SN  - 2210-6014
UR  - https://doi.org/10.1016/j.jegh.2015.04.002
DO  - 10.1016/j.jegh.2015.04.002
ID  - Myneedu2015
ER  -

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