Suplementation of Vitamin D in Patients with Pulmonary Tuberculosis Ethnic Batak

DOI

10.2991/phico-16.2017.22How to use a DOI?

Keywords

vitamin D, pulmonary tuberculosis, sputum conversion, ApaI polymorphism of the VDR gene, ethnic Batak

Abstract

Vitamin D has a complex action on the immune system, among other cathelicidin production stimulator which enhances phagocytosis magrofag. TB is an infectious disease which causes high mortality and morbidity in the world. Vitamin D will give the effect when it binds to its receptor (VDR). Variants VDR gene polymorphism associated with susceptibility and resistance to pulmonary tuberculosis. Objective: to determine the effect of vitamin D in patients with pulmonary tuberculosis against ethnic Batak The study design with RCT, Ninety-two people with pulmonary TB smear positive new cases of ethnic Batak in Medan were randomized to receive 100,000 IU doses administered at 4 doses. Assessment were performed at 14, 28, 42, and 56 days. Levels of vitamin D beginning and end checked with ELISA techniques and ApaI polymorphisms of genes RVD checked by PCR RFLP. After two months of 86 patients who met the inclusion criteria as many as 40 people with vitamin D intervention and 46 to placebo. Sputum conversion times faster intervention group than placebo (p <0.05) with increased levels of vitamin D is much different (95.31% and placebo interventions 6.81%). 5) dengan peningkatan kadar vitamin D jauh berbeda (intervensi 95,31% dan plasebo 6,81%). Sputum conversion based ApaI VDR gene polymorphisms in the two groups was not significant (p> 0.05). Vitamin D proven to accelerate the conversion of sputum in the study population of patients with pulmonary TB ethnic Batak. ApaI polymorphism of the VDR gene genotype Aa and aa more conversions at 42 days while the AA genotype at 56 days.

Copyright

© 2017, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Nita Andriani Lubis
AU  - Melviana Melviana
AU  - Bintang Y.M. Sinaga
AU  - Yahwardiah Siregar
PY  - 2016/12
DA  - 2016/12
TI  - Suplementation of Vitamin D in Patients with Pulmonary Tuberculosis Ethnic Batak
BT  - Proceedings of the 1st Public Health International Conference (PHICo 2016)
PB  - Atlantis Press
SP  - 107
EP  - 111
SN  - 2468-5739
UR  - https://doi.org/10.2991/phico-16.2017.22
DO  - 10.2991/phico-16.2017.22
ID  - AndrianiLubis2016/12
ER  -