Platelet to Lymphocytes Ratio in the Clinical Stage of Nasopharyngeal Carcinoma

DOI

10.2991/978-94-6463-280-4_44How to use a DOI?

Keywords

Nasopharyngeal carcinoma; Head and neck cancer; Platelet to Lymphocyte Ratio

Abstract

Background: Nasopharyngeal carcinoma (NPC) is an undifferentiated form of squamous cell carcinoma arising from the epithelium of the nasopharynx and is the most common head and neck cancer in Southeast Asia. Inflammation has been shown to have a significant influence on tumor growth in humans. Platelet to lymphocyte ratio (PLR) is an inflammation-based test that is simple and inexpensive to obtain, and it has the potential to be used in the evaluation of NPC as a tumor development assessment. Objective: In nasopharyngeal carcinoma, PLR is expected to be a tumor progression marker. The goal of this study is to assess PLR levels in NPC patients. Method: This was a case-control study that used data from the Nasopharyngeal Cancer Register System of the Indonesian Association of Ear, Nose, and Throat Head and Neck Surgeons’ Head and Neck Surgical Oncology Study Group (PERHATI-KL). The inclusion criteria were met by 383 patients in total. Result: T1 has the lowest average in the T classification (238.7), while T4 has the highest average (258.8). The average PLR value increases in the N classification, from N0 to N3, from 220.5 to 285.5. Classification M has the same results, with M1 having a higher average (353.9) compared to M0 (245.7). Similar results were found in the staging group, wherein stage I (108.6) and stage IVB (340.4), higher staging corresponded to higher mean PLR values. Conclusion: The highest PLR value is in T4, N3, and M1 classification. The clinical stage with the highest PLR value is IVB.

Copyright

© 2023 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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TY  - CONF
AU  - Goesti Yudistira
AU  - Yussy Afriani Dewi
AU  - Melati Sudiro
PY  - 2023
DA  - 2023/10/31
TI  - Platelet to Lymphocytes Ratio in the Clinical Stage of Nasopharyngeal Carcinoma
BT  - Proceedings of the 19 th Otorhinolaryngology head and neck surgery national congress (PERHATIKL 2022)
PB  - Atlantis Press
SP  - 243
EP  - 247
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6463-280-4_44
DO  - 10.2991/978-94-6463-280-4_44
ID  - Yudistira2023
ER  -