Bacterial resistance and virulence markers in urine of HIV patients and pregnant women in Port Harcourt, Nigeria

DOI

10.2991/978-94-6463-306-1_11How to use a DOI?

Keywords

Antibiotics; HIV patients; Pregnant women; Resistance; Uropathogens

Abstract

The present study was carried out to ascertain resistance pattern in Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa in urine samples of HIV patients and pregnant women attending the University of Port Harcourt Teaching Hospital. A total of one hundred and thirty (130) urine samples were collected from HIV patients and equal number for pregnant women. The midstream urine samples were cultured on cystine lactose electrolyte deficient agar (CLED) media. Isolates were identified for the presence of Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa. Antibiotic susceptibility testing was performed on identified isolates by Kirby-Bauer’s disc diffusion method. Results from the study revealed that 2.31% men and 10.76% female were positive for HIV while 29.23% were positive for pregnant women. Four uropathogens occurred in HIV patients while eight pathogens in pregnant women with Escherichia coli (72.22%) and Klebsiella pneumoniae (34.04) as the highest occurring uropathogens respectively. The least occurred uropathogens were Pseudomonas aeruginosa and Proteus sp. (5.56% for each) in HIV patients and Enterobacter aerogenes (2.13%) and Alcaligenes faecalis (2.13%) in pregnant women. The rate of infections were highest among pregnant women in their third trimesters (65.75%) and HIV patients less than 5 years on antiretroviral drugs (52.94%). All isolates were highly resistant to Imipenem/Cilastacin, Amoxicillin and Cefuroxime while most isolates were 100% susceptible to Ofloxacin and Levofloxacin antibiotics. Pseudomonas aeruginosa showed high multidrug resistance in pregnant women. There is need to create awareness on uropathogens, factors leading to their acquisition, prevention, testing and treatment should be increased at trimesters in pregnancy and HIV patient’s routine check-up.

Copyright

© 2023 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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TY  - CONF
AU  - K. Onwubuche
AU  - O. E. Agbagwa
AU  - N. Frank-Peterside
PY  - 2023
DA  - 2023/12/18
TI  - Bacterial resistance and virulence markers in urine of HIV patients and pregnant women in Port Harcourt, Nigeria
BT  - Proceedings of the 6th Biennial Conference of Organization for Women in Science for the Developing World Nigeria (OWSD 2023)
PB  - Atlantis Press
SP  - 175
EP  - 187
SN  - 2468-5747
UR  - https://doi.org/10.2991/978-94-6463-306-1_11
DO  - 10.2991/978-94-6463-306-1_11
ID  - Onwubuche2023
ER  -