Proceedings of the 2nd Global Health and Innovation in conjunction with 6th ORL Head and Neck Oncology Conference (ORLHN 2021)

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Association of Toll-Like Receptor-3 Polymorphism with Nasopharyngeal Carcinoma in The Minangkabau Ethnic Group

Authors
Putri Sari Ivanny1, 2, *, Sukri Rahman1, 2, Al Hafiz1, 2, Hirowati Ali3, Hafni Bachtiar4
1Department of Otorhinolaryngology – Head and Neck Surgery, Faculty of Medicine Andalas University, Padang, Indonesia
2Dr. M. Djamil General Hospital, Padang, Indonesia
3Department of Biochemical Science, Faculty of Medicine Andalas University, Padang, Indonesia
4Department of Public Health, Faculty of Medicine Andalas University, Padang, Indonesia
*Corresponding author. Email: putri.ivanny@gmail.com
Corresponding Author
Putri Sari Ivanny
Available Online 21 February 2022.
DOI
10.2991/ahsr.k.220206.027How to use a DOI?
Keywords
Nasopharyngeal Carcinoma; Toll-Like Receptor-3; Epstein-Barr virus; Minangkabau
Abstract

Nasopharyngeal carcinoma (NPC) is an epithelial malignancy in the head and neck region that has a unique geographic distribution and is closely related to Epstein-Barr Virus (EBV) infection. The growth of malignancy due to viruses is largely determined by the host immune response. Toll-Like Receptors (TLRs) emerged as important components of the innate immune system playing an important role in sensitizing, controlling, destroying pathogens and responding to viral infections. TLR3 single nucleotide polymorphisms (SNPs) are thought to affect individual susceptibility to cancer. This inherited polymorphism has an impact on the heterogeneity of the immune system response in the form of changes in antiviral function and effects. This comparative analytic study used a cross sectional comparative study design on 23 Minangkabau ethnic NPC patients and 23 healthy Minangkabau ethnicity patients as controls. Respondents were examined for TLR3 gene polymorphism by polymerase chain reaction sequence (PCR) sequencing method. Data were analyzed statistically with a computer program and declared significant if p<0.05. TLR3 polymorphisms (rs3775291) were found in both the NPC and control groups in the form of homozygous mutants and heterozygous mutants. Homozygous mutants were found in the NPC group as much as 21.7%, while in the control group it was 30.4%. Heterozygous mutants were found in the NPC group as much as 39.1%, while in the control group as much as 34.8%. Statistically there was no significant relationship between TLR3 polymorphism (rs3775291) and the incidence of NPC with p> 0.05. There is no relationship between TLR3 polymorphism (rs3775291) and the incidence of NPC in the Minangkabau ethnic group.

Copyright
© 2022 The Authors. Published by Atlantis Press International B.V.
Open Access
This is an open access article under the CC BY-NC license.

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Volume Title
Proceedings of the 2nd Global Health and Innovation in conjunction with 6th ORL Head and Neck Oncology Conference (ORLHN 2021)
Series
Advances in Health Sciences Research
Publication Date
21 February 2022
ISBN
10.2991/ahsr.k.220206.027
ISSN
2468-5739
DOI
10.2991/ahsr.k.220206.027How to use a DOI?
Copyright
© 2022 The Authors. Published by Atlantis Press International B.V.
Open Access
This is an open access article under the CC BY-NC license.

Cite this article

risenwbib
TY  - CONF
AU  - Putri Sari Ivanny
AU  - Sukri Rahman
AU  - Al Hafiz
AU  - Hirowati Ali
AU  - Hafni Bachtiar
PY  - 2022
DA  - 2022/02/21
TI  - Association of Toll-Like Receptor-3 Polymorphism with Nasopharyngeal Carcinoma in The Minangkabau Ethnic Group
BT  - Proceedings of the 2nd Global Health and Innovation in conjunction with 6th ORL Head and Neck Oncology Conference (ORLHN 2021)
PB  - Atlantis Press
SP  - 134
EP  - 142
SN  - 2468-5739
UR  - https://doi.org/10.2991/ahsr.k.220206.027
DO  - 10.2991/ahsr.k.220206.027
ID  - Ivanny2022
ER  -