Correlation of Serum Ferritin Levels with Creatinine, Sgot and Sgpt Levels in Thalassemia Major Patients

DOI

10.2991/978-2-38476-022-0_116How to use a DOI?

Keywords

Thalassemia; Ferritin; Creatinine; SGOT; SGPT

Abstract

Thalassemia major patients receive regular blood transfusions every 2–5 weeks, to maintain pretransfusion hemoglobin levels above 9–10.5 g/dl. In patients with thalassemia major, continuous blood transfusion can cause iron overload by increased serum ferritin levels. Accumulated iron is toxic to many tissues causing dysfunction and failure of major organs, including the heart, kidneys, liver and endocrine glands (pituitary, thyroid, parathyroid, and pancreas). This study aims to determine the relationship between ferritin levels with creatinine, SGOT and SGPT in patients with thalassemia major. This research is observational with data collection using a cross-sectional method. The study population was 65 medical records of thalassemia major patients at Hermina Jatinegara Hospital, Indonesia, in 2019. The analytical method used is the Kruskal Wallis test and the Spearman correlation test. The results obtained were that the average levels of ferritin, creatinine, AST and ALT were 2952.23 ng/mL, 0.52 mg/dL, 32.37 /L and 32.33/L. The results of the Kruskal-Wallis test showed that the levels of ferritin and creatinine had a significant difference based on age (p 0.041 and p 0.049). The Spearman correlation test results showed a positive correlation between serum ferritin and SGPT (p 0.02) with a coefficient correlation of 0.289. There is no correlation between serum ferritin, SGOT and Creatinine (p 0.17 & p 0.73). Based on these results, serum ferritin levels have a weak correlation with SGPT levels and do not correlate with other parameters.

Copyright

© 2023 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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TY  - CONF
AU  - Fatwa Hasbi
AU  - Harpolia Cartika
PY  - 2023
DA  - 2023/05/13
TI  - Correlation of Serum Ferritin Levels with Creatinine, Sgot and Sgpt Levels in Thalassemia Major Patients
BT  - Proceedings of the 1st UMSurabaya Multidisciplinary International Conference 2021 (MICon 2021)
PB  - Atlantis Press
SP  - 1041
EP  - 1049
SN  - 2352-5398
UR  - https://doi.org/10.2991/978-2-38476-022-0_116
DO  - 10.2991/978-2-38476-022-0_116
ID  - Hasbi2023
ER  -