The Preparation and Biological Toxicity Research of the New Controlled Release Carrier Nano-silica

DOI

10.2991/mic-15.2015.47How to use a DOI?

Keywords

TEOS hydrolysis method; nano silica; biocompatibility

Abstract

The different particle sizes’ nano silica spheres are synthesized by the TEOS hydrolysis method. The XRD patterns testified that the sample is single phase and its strongest peak is significantly broadened. From the photos of TEM we can see that the samples’ surfaces have a good dispersion and uniform spherical morphology. The Hela cell proliferating activity is assessed by MTT assay, combined with the cell morphology and Annexin Hoechst 33342 staining are employed to determine apoptosis in Hela cells. Results shows that while the Hela cell treated with different concentrations of 200nm nano silica, cytocompatibility becomes better with the lower concentrations of nano silica. 24h cells stained photograph shows that under the concentrations of nano silica 50 g·ml-1 the cell structure is normal and nucleus is complete.

Copyright

© 2015, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Li Xinxin
AU  - Zhang Wenjuan
AU  - Tong Bobo
AU  - Zheng Xiang
AU  - Zhao Yali
AU  - Wang Zhilong
PY  - 2015/08
DA  - 2015/08
TI  - The Preparation and Biological Toxicity Research of the New Controlled Release Carrier Nano-silica
BT  - Proceedings of the 2nd International Conference on Modelling, Identification and Control
PB  - Atlantis Press
SP  - 208
EP  - 211
SN  - 1951-6851
UR  - https://doi.org/10.2991/mic-15.2015.47
DO  - 10.2991/mic-15.2015.47
ID  - Xinxin2015/08
ER  -