Manganese-Induced Effects on Calcium Homeostasis of the Neurons in Hyline Cocks
Authors
Xiaofei Liu, Lirong Jing, Lv Xue, Yongqiang Ma, Huanan Guan, Wang Wei
Corresponding Author
Xiaofei Liu
Available Online April 2015.
- DOI
- 10.2991/mebe-15.2015.34How to use a DOI?
- Keywords
- Manganese; Calcium Homeostasis; Neurons; Cocks
- Abstract
Manganese (Mn) is known to be essential for maintaining the proper function and regulation of many biochemical. To investigate the toxicity of Mn on bird brains, 50-day-old cocks were fed either a commercial diet or a Mn-supplemented diet. the following were determined: Mn concentration, Ca2+ concentration, the expression of Calmodulin (CaM) and Calcineurin (CaN) gene. Exposure to Mn significantly lowered expression of CaM and CaN gene. However, Mn was accumulated in brain and the Ca2+ concentration was increased. These findings suggested that Mn exposure resulted in the damage of cock cerebral tissue by altering calcium homeostasis, which are possible underlying neurotoxicity mechanisms.
- Copyright
- © 2015, the Authors. Published by Atlantis Press.
- Open Access
- This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).
Cite this article
TY - CONF AU - Xiaofei Liu AU - Lirong Jing AU - Lv Xue AU - Yongqiang Ma AU - Huanan Guan AU - Wang Wei PY - 2015/04 DA - 2015/04 TI - Manganese-Induced Effects on Calcium Homeostasis of the Neurons in Hyline Cocks BT - Proceedings of the 2015 International Conference on Materials, Environmental and Biological Engineering PB - Atlantis Press SP - 139 EP - 142 SN - 2352-5401 UR - https://doi.org/10.2991/mebe-15.2015.34 DO - 10.2991/mebe-15.2015.34 ID - Liu2015/04 ER -