The Correlation of HbA2 Levels Against The Mentzer Index in Patients Diagnosed with Thalassemia in A Private Laboratory Around Central Java

DOI

10.2991/978-94-6463-457-0_3How to use a DOI?

Keywords

HbA2; Mentzer Index; Thalassemia

Abstract

Hemoglobin electrophoresis is the gold standard for thalassemia carriers screening. Hemoglobin electrophoresis sees an increase in HbA2, where thalassemia patients experience abnormalities in the composition of HbA2. The Mentzer index is a discrimination index formula with good sensitivity, specificity, accuracy, and positive predictive value in determining iron deficiency anemia or thalassemia. The aim of this study was to determine the correlation between HbA2 and the Menzer index in patients diagnosed with thalassemia at a private laboratory in Central Java. The study was conducted in January 2022-May 2023 with samples of 30 data from the results of Hb electrophoresis and routine complete blood counts in patients diagnosed with thalassemia in the CITO Laboratory. The results of the Rank Spearman correlation test concluded that there was a significant correlation with a negative coefficient pattern (r=-0.398), this means that the variables are said to be not unidirectional, meaning that if the HbA2 variable increases, the Menzter index variable will decrease, and vice versa. The Mentzer index is calculated from the results of a complete blood count, if the MCV divided by erythrocytes is less than 13, then it is declared as thalassemia. But if the result is greater than 13, then it is expressed as iron deficiency anemia. Patients with thalassemia found an increase in HbA2 levels by reading using the Mentzer index for thalassemia patients which is less than 13. The higher the HbA2 level, the Mentzer index value will be lower than 13.

Copyright

© 2024 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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TY  - CONF
AU  - Sri Indah Kusumawati
AU  - Andri Sukeksi
AU  - Gela Setya Ayu Putri
PY  - 2024
DA  - 2024/07/22
TI  - The Correlation of HbA2 Levels Against The Mentzer Index in Patients Diagnosed with Thalassemia in A Private Laboratory Around Central Java
BT  - Proceedings of the 2nd Lawang Sewu International Symposium on Health Sciences: Medical Laboratory Technology (LSISHS-MLT 2023)
PB  - Atlantis Press
SP  - 16
EP  - 22
SN  - 2468-5747
UR  - https://doi.org/10.2991/978-94-6463-457-0_3
DO  - 10.2991/978-94-6463-457-0_3
ID  - Kusumawati2024
ER  -