Pharmaceutical Composition Based on Two Innovative Chitosan-Containing Substances – The Chitosan-Chymopsin Complex and the Chitosan-Miramistin Complex – for Production of a Finished Dosage Form for the Treatment of Infected Wounds of Various Origins
- DOI
- 10.2991/isils-19.2019.15How to use a DOI?
- Keywords
- chitosan-miramistin complex, chitosan-chymopsin complex, treatment of infected wounds of various origins, lysozyme, chlorhexidine, miramistin, hydroxypropyl methylcellulose (HPMC), polyacrylamide (PAM)
- Abstract
Developed pharmaceutical composition based on two innovative chitosan-containing substances: the chitosan-chymopsin complex and the chitosan-miramistin complex, for the treatment of infected wounds in gel dosage form for external use has four types of pharmacological effects - necrolytic, antimicrobial, wound healing and analgesic. The chitosan-chymopsin complex provides prolonged proteolytic action of the enzyme, restores microcirculation in wound walls, improves metabolic processes and relieves local inflammation. The chitosan-miramistin complex has a pronounced bactericidal effect against aerobic and anaerobic bacteria, gram-positive and gram-negative microorganisms, both in the form of monocultures and in the form of associations, including hospital strains with antibiotic resistance. Gel as a dosage form provides indirect anaesthetic effect due to cooling effect when applied to the damaged surface.
- Copyright
- © 2019, the Authors. Published by Atlantis Press.
- Open Access
- This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).
Cite this article
TY - CONF AU - Liliana Brkich AU - Tatiana Salnikova AU - Natalia Pyatigorskaya AU - Galina Brkich AU - Vasily Belyaev PY - 2019/11 DA - 2019/11 TI - Pharmaceutical Composition Based on Two Innovative Chitosan-Containing Substances – The Chitosan-Chymopsin Complex and the Chitosan-Miramistin Complex – for Production of a Finished Dosage Form for the Treatment of Infected Wounds of Various Origins BT - Proceedings of the 1st International Symposium Innovations in Life Sciences (ISILS 2019) PB - Atlantis Press SP - 169 EP - 171 SN - 2468-5747 UR - https://doi.org/10.2991/isils-19.2019.15 DO - 10.2991/isils-19.2019.15 ID - Brkich2019/11 ER -