The Role of Local Porang Glucomannan and Its Hydrolysate in Diabetes Mellitus Management: An Experimental Study on Rat

DOI

10.2991/978-94-6463-908-7_5How to use a DOI?

Keywords

Blood glocose level; Porang Glucomannan; Kalimantan Timur

Abstract

Diabetes Mellitus (DM) refers to a group of metabolic disorders marked by elevated blood glucose levels, which occur as a result of abnormalities in insulin production, its effectiveness, or a combination of both. Combination therapy for DM patients includes dietary intake and increased physical activity. Functional foods are known to be a beneficial food source for improving health. Porang Flour (GP) is a food source rich in glucomannan content, and its hydrolysis product (GPA) is claimed to be a prebiotic that, in sufficient quantities, can increase the population of beneficial gut microbiota and produce secondary metabolites beneficial to health. The effects of local porang glucomannan from East Kalimantan and GPA can be used as a therapeutic diet for diabetes. The study was conducted using a pre-test and post-test control group design, testing the efficacy of porang glucomannan through glucose loading and glucose level testing in mice. Glucose loading in mice was performed with four treatments in the control group, Porang flour (K2), Porang glucomannan flour (K3), and commercial glucomannan flour (K4), with a dose of 0.9 g/200g observed over 120 min. Meanwhile, the efficacy test was conducted by administering a diet to streptozotocin nicotinamide-induced diabetic mice. The diabetic mice were treated via sondage for 21 days, with GP and GPA diets in each group at doses of 100, 200, and 400 mg/kg BW. The result showed GPA2 with dose 200 mg/kg was found to reduce blood glucose levels. GPA2 treatment showed a potential therapeutic agent and additional alternative for lowering blood sugar levels in diabetes to prevent hyperglicemic condition.

Copyright

© 2025 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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TY  - CONF
AU  - Anggela Anggela
PY  - 2025
DA  - 2025/12/07
TI  - The Role of Local Porang Glucomannan and Its Hydrolysate in Diabetes Mellitus Management: An Experimental Study on Rat
BT  - Proceedings of the International Conference on Innovation in Food Science, Culinary Art, and Fashion Technology (INNOFATEC 2025)
PB  - Atlantis Press
SP  - 53
EP  - 61
SN  - 2352-5398
UR  - https://doi.org/10.2991/978-94-6463-908-7_5
DO  - 10.2991/978-94-6463-908-7_5
ID  - Anggela2025
ER  -