Pathological effects of the renin-angiotensin system on cardiovascular disease

DOI

10.2991/icsste-15.2015.19How to use a DOI?

Keywords

renin - angiotensin system; angiotensin-converting enzyme 2; cardiovascular disease

Abstract

the renin -angiotensin system (RAS) found in a research as a new member, changes the past view that only the angiotensin (Ang) catalyzed by angiotensin-converting enzyme (ACE) can produce pathogenic role. The research proved the renin binding with former prime renin –receptor (RPR) and Ang binding with insulin receptor regulated aminopeptidase (IRAP) will also produce the same pathogenic role. The newly discovered ACE2 catalyzes Ang- (1-7) and Ang- (1-9) generation, then the receptor of Ang- (1-7) and Mas and the receptor of Ang- (1-9) and AT2 binding, may produce cardiovascular protective effect, but the pathogenic role of RAS is still dominant. The discovery of RAS new member provides a new theoretical basis to recognize RAS inhibitors in clinical research results.

Copyright

© 2015, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Zhang Yan
PY  - 2015/04
DA  - 2015/04
TI  - Pathological effects of the renin-angiotensin system on cardiovascular disease
BT  - Proceedings of the 2015 International Conference on Social Science and Technology Education
PB  - Atlantis Press
SP  - 58
EP  - 60
SN  - 2352-5398
UR  - https://doi.org/10.2991/icsste-15.2015.19
DO  - 10.2991/icsste-15.2015.19
ID  - Yan2015/04
ER  -