Research on Effects of Herb of Glabrous Sarcandra on Human Prostate Carcinoma DU-145 Cells PI3K / m TOR Signal Transduction Pathway

DOI

10.2991/icmmbe-16.2016.128How to use a DOI?

Keywords

Herb of Glabrous Sarcandra, Human Prostate Carcinoma, DU-145 Cells, PI3K / m TOR Signal Transduction Pathway

Abstract

In order to investigate the effect of herb of glabrous sarcandra solution on human prostate cancer DU-145 cells PI3K / m TOR signal transduction pathway, the paper uses method of cell culture, with Sarcandrae solution with different concentrations of 48h, the impact on DU-145 cells were detected by MTT solution herb of glabrous sarcandra method of DU-145 cell proliferation by RT - PCR detected after treatment cells PI3K, mTOR and P70S6K gene expression. Herb of glabrous sarcandra action of wind solution after 48h, DU-145 cell proliferation was inhibited and showed dose-effect relationship; DU-145 cells expressing the P13K, mTOR and P7OS6K showed different degrees of inhibition, it does not show a dose relationship. This indicates herb of glabrous sarcandra solution can inhibit human prostate cancer DU-145 cell proliferation, cell proliferation inhibition mechanism related to the inhibition of cell P13K / mTOR signaling pathway effects.

Copyright

© 2016, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Xiuxia Wang
PY  - 2016/09
DA  - 2016/09
TI  - Research on Effects of Herb of Glabrous Sarcandra on Human Prostate Carcinoma DU-145 Cells PI3K / m TOR Signal Transduction Pathway
BT  - Proceedings of the6th International Conference on Mechatronics, Materials, Biotechnology and Environment (ICMMBE 2016)
PB  - Atlantis Press
SP  - 688
EP  - 691
SN  - 2352-5401
UR  - https://doi.org/10.2991/icmmbe-16.2016.128
DO  - 10.2991/icmmbe-16.2016.128
ID  - Wang2016/09
ER  -