Effect on Hep-1cell Calcium Homeostasis after Aβ25-35 Injury
- 10.2991/icmmbe-16.2016.77How to use a DOI?
- Calcium Homeostasis; Aβ25-35; Alzheimer's disease
The purpose of this study was to observe the effect of β-amyloid protein injury on intracellular calcium homeostasis in Hep-1 cells. Aβ25-35 was used to build the Hep-1 cell model of AD. Intracellular Calcium measurements was performed by incubation with the calcium indicator probe and then observed under laser confocal microscopy. Ca2+ release from intracellular stores was significantly increased in immortal human endothelial cells (SK-Hep-1) after injury induced by Aβ25-35. No significant difference was found in CCE from injured cells to controls. Increased β-amyloid protein production and intracellular calcium homeostasis disturbance were pathological mechanisms relate to AD.
- © 2016, the Authors. Published by Atlantis Press.
- Open Access
- This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).
Cite this article
TY - CONF AU - Wenzhao Liang AU - Bing Yan AU - Mingzhu Yu AU - Yankun Shao AU - Jinting He PY - 2016/09 DA - 2016/09 TI - Effect on Hep-1cell Calcium Homeostasis after Aβ25-35 Injury BT - Proceedings of the6th International Conference on Mechatronics, Materials, Biotechnology and Environment (ICMMBE 2016) PB - Atlantis Press SP - 410 EP - 413 SN - 2352-5401 UR - https://doi.org/10.2991/icmmbe-16.2016.77 DO - 10.2991/icmmbe-16.2016.77 ID - Liang2016/09 ER -