Arterial Hypertension under Combined Effect of Metals in Experiments on Rats

DOI

10.2991/ichw-19.2019.9How to use a DOI?

Keywords

arterial hypertension, cadmium, cobalt, zinc, calcium

Abstract

In experiments on 120 Wistar rats, changes in systemic hemodynamics were studied under intragastric daily injections of cadmium sulfate (0.5 mg/kg per metal), cobalt chloride (4 mg/kg per metal), zinc chloride separately and together with cadmium or cobalt at a dose of 20 mg/kg or 1 mg/kg (per metal). Changes in average arterial pressure were studied by the method of electromomanometry, and in the cardiac output - by the thermodilution method. Specific peripheral vascular resistance was calculated. The content of calcium and metals in the blood and bone tissue, and the content of ionized calcium in blood were determined. The correlation analysis of the parameters using the Pearson method was conducted. The results of the study revealed development of arterial hypertension after the injection of metals due to an increase in specific peripheral vascular resistance. Cardiac output decreased indicating a violation of the pumping function of the heart. The correlation between an increase in blood pressure and the content of ionized calcium was established. Accumulated metals in the bones causing their decalcification were identified. Under the combined injection of metals and zinc, it was found that high doses of zinc (20 mg/kg) do not prevent arterial hypertension from developing. Small doses (1 mg/kg) have a significant prophylactic effect.

Copyright

© 2019, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - V.B. Brin
AU  - O.T. Kabisov
AU  - D.Kh. Oganesyan
AU  - K.G. Mittsiev
AU  - A.K. Mittsiev
PY  - 2019/10
DA  - 2019/10
TI  - Arterial Hypertension under Combined Effect of Metals in Experiments on Rats
BT  - Proceedings of the International Conference on Health and Well-Being in Modern Society (ICHW 2019)
PB  - Atlantis Press
SP  - 37
EP  - 41
SN  - 2468-5739
UR  - https://doi.org/10.2991/ichw-19.2019.9
DO  - 10.2991/ichw-19.2019.9
ID  - Brin2019/10
ER  -