Proceedings of the 5th International Conference on Health Sciences (ICHS 2018)

The Effect of Red Dragon Fruit Extract (Hylocereus Polyrhizus) on Membrane Lipid Peroxidation and Liver Tissue Damage Triggered by Hyperlipidemia in White Rats (Rattus Norvegicus)

Authors
Maria Selvester Thadeus, Cut Fauziah, Fajriati Zulfa, Anisah
Corresponding Author
Maria Selvester Thadeus
Available Online November 2019.
DOI
https://doi.org/10.2991/ichs-18.2019.23How to use a DOI?
Keywords
Red Dragon Fruit Extract (Hylocereus Polyrhizus), Hyperlipidemia, Membrane Lipid Peroxidation, Rattus Norvegicus
Abstract
This study aims to prove that the administration of red dragon fruit extract (Hylocereus polyrhizus) has an effect on membrane lipid peroxidation and liver tissue damage triggered by hyperlipidemia in white rats (Rattus norvegicus). This study used trueexperimental design with using 30 male Wistar rats which were divided into 5 groups. Group K1 - K4 was given treatment for 8 weeks and group K5 for 16 weeks. The group consists of K1 negative control (standard diet); K2 positive control (standard diet and quail eggs 10 ml / kgBW); K3 (standard diet, quail eggs 10 ml / kgBW and simvastatin 0.72 mg / day); K4 (standard diet, quail eggs 10 ml / kgBW and red dragon fruit extract dose 60 mg / day) for 8 weeks and K5 (standard diet, quail eggs 10 ml / kgBW and red dragon fruit extract dose 60 mg / day) for 16 weeks. Data was analyzed by One Way ANOVA test, followed by the Wilcoxon Man-Whitney Post Hoc test (P-value <0.05) in 8 weeks treatment. K3 and K4 groups showed improvement in MDA concentration and improvement of liver tissue (P-value <0.05) compared to K2. Red dragon fruit extract 60 mg/day has a potential effect in repairing lipid peroxidation damage on liver cell membrane in hyperlipidemia conditions with high fat diet.
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This is an open access article distributed under the CC BY-NC license.

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Proceedings
5th International Conference on Health Sciences (ICHS 2018)
Publication Date
November 2019
ISBN
978-94-6252-824-6
DOI
https://doi.org/10.2991/ichs-18.2019.23How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - CONF
AU  - Maria Selvester Thadeus
AU  - Cut Fauziah
AU  - Fajriati Zulfa
AU  - Anisah
PY  - 2019/11
DA  - 2019/11
TI  - The Effect of Red Dragon Fruit Extract (Hylocereus Polyrhizus) on Membrane Lipid Peroxidation and Liver Tissue Damage Triggered by Hyperlipidemia in White Rats (Rattus Norvegicus)
BT  - 5th International Conference on Health Sciences (ICHS 2018)
PB  - Atlantis Press
UR  - https://doi.org/10.2991/ichs-18.2019.23
DO  - https://doi.org/10.2991/ichs-18.2019.23
ID  - Thadeus2019/11
ER  -