Antifungal Combination of Miconazole and Sulfur for the Treatment of Dermatophytosis

DOI

10.2991/978-94-6463-112-8_73How to use a DOI?

Keywords

Dermatophytosis; miconazole; sulfur; combination

Abstract

Dermatophytosis is a fungal infection of keratinized tissue (skin, hair, and nails) caused by three genera of dermatophytes: Epidermophyton, Microsporum, and Trichophyton. Dermatophytosis is a zoonotic disease that easily spreads to other animals as well as to humans. Long treatment will give great loss not only to livestock but also to humans. Miconazole and sulfur are antifungals that have often been used to treat fungal-caused dermatophytosis. The purpose of this study was to obtain the composition of sulfur and miconazole combination which was effective in killing dermatophytes fungus. The fungus used was Trychophyton mentagrophytes. The antifungal doses used were single miconazole with a graded dose of 10mg/g, sulfur with a graded dose of 30 mg/g, and a combination of miconazole and sulfur. The test method used was the diffusion test to see the width of the inhibition zone and the dilution test (pour plate) to calculate the growth of the fungus. The concentration of fungus used for the test was 10⁶ cfu/ml. Solutions of antifungal and fungus active ingredients were tested using Sabouraud Dextrose Agar media. The results of the in vitro test showed that the width of the inhibition zone on miconazole 10 mg/g was 35.2 mm (diffusion test) with 0 fungal growth (dilution test). Sulfur concentration 30 mg/g the inhibition zone was 4,83 mm (diffusion test) with 34 cfu/ml fungus growth (dilution test). In the combined of sulfur 7,5 mg/g and miconazole 5 mg/g, the width of the inhibition zone was 30.3 mm with the growth of fungus colonies is 0. Based on the results of the diffusion and dilution tests, the best combination composition between sulfur and miconazole was obtained at a concentration of 7,5 mg/g sulfur and 5 mg/g miconazole.

Copyright

© 2023 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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TY  - CONF
AU  - Dwi Endrawati
AU  - Ermayati Ermayati
AU  - Suherman Suherman
AU  - Eni Kusumaningtyas
AU  - Riza Z. Ahmad
PY  - 2023
DA  - 2023/03/01
TI  - Antifungal Combination of Miconazole and Sulfur for the Treatment of Dermatophytosis
BT  - Proceedings of the 1st International Conference for Health Research – BRIN (ICHR 2022)
PB  - Atlantis Press
SP  - 807
EP  - 813
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6463-112-8_73
DO  - 10.2991/978-94-6463-112-8_73
ID  - Endrawati2023
ER  -