Study of Tablet Formulations Containing a Combination of Secang (Caesalpinia sappan L) and Gambir (Uncaria Gambir Hunter Roxb) Extracts as Uric Acid Lowering Agents

DOI

10.2991/978-94-6463-112-8_67How to use a DOI?

Keywords

Gambir; secang; uric acid-lowering formula extract; tablet dosage form; direct compression

Abstract

The number of people with hyperuricemia tends to increase in line with the growth in the level of community welfare. The proportional combination of secang and gambir extract (formula extract = FE) was proven to be able to reduce blood uric acid levels with an effective dose of 75 mg/kg bw (body weight) in hyperuricemia rats. This study aimed to design FE into the final dosage form of tablets. The drying process of each semisolid extract was carried out using five types of fillers (dextrin, maltodextrin, cornstarch, lactose and amprotab) with a ratio of 1:1 to 1:3 of each extract and filler using a vacuum oven. The designed extract powder of secang and gambir was accessed based on the following parameters: water content, angle of repose degree, and total phenol content. The selected of each powder extract was prepared using a ratio of 1:1 extract to corn starch for secang and a 1:1 ratio (extract: amprotab) for gambir powder extract. FE was prepared by combining the proportional amounts of the selected secang and gambir powder. Furthermore, the tablet formulation of FE was composed by the direct compression (DC) method using different disintegrants, namely, amprotab (Formula A) and explotab (Formula B). Evaluation of both granulated masses demonstrated that all parameters complied with the requirement. Furthermore, evaluation of the final tablet physical properties revealed that formulation with 8% explotab as a disintegrant agent performed better than formulation with 8% amprotab. Tablet properties of Formula B fulfilled the pharmacopeia requirements, namely, mean weight 767.0 ± 17.8 (mg), hardness 4.01–6.60 (kg/cm²), friability 0.7 (%), and disintegration time 13.0–15.0 (min).

Copyright

© 2023 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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TY  - CONF
AU  - Sri Ningsih
AU  - Nisrina Firdausi
AU  - Julham Efendi
AU  - Nizar Nizar
AU  - Fahleni Fahleni
PY  - 2023
DA  - 2023/03/01
TI  - Study of Tablet Formulations Containing a Combination of Secang (Caesalpinia sappan L) and Gambir (Uncaria Gambir Hunter Roxb) Extracts as Uric Acid Lowering Agents
BT  - Proceedings of the 1st International Conference for Health Research – BRIN (ICHR 2022)
PB  - Atlantis Press
SP  - 740
EP  - 751
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6463-112-8_67
DO  - 10.2991/978-94-6463-112-8_67
ID  - Ningsih2023
ER  -