Subacute Toxicity of Water Fraction of Africa Leaves (Vernonia amygdalina Del.) on Blood Parameters in Male White Mice

DOI

10.2991/ahsr.k.211105.040How to use a DOI?

Keywords

African leaves; Vernonia amygdalina Del.; water fraction; subacute toxicity; blood parameters

Abstract

African leaves (Vernonia amygdalina Del.) is one of the plants used as traditional medicine. Although natural, traditional medicinal ingredients are not necessarily safe for use in humans. In this study, a subacute toxicity test of Afrian leaves water fraction was carried out on male white mice. This study aims to determine the effect of dosage variations and duration of administration of water fraction of African leaves (Vernonia amygdalina Del.) on blood parameters. Parameters observed were erythrocytes, leukocytes, haemoglobin and hematocrit. The experimental animals used were 36 male white mice which were divided into four groups. The first group as a negative control was given 0.5% Na CMC suspension, while three more groups were given test preparations at a dose of 10 mg/kg BW, 20 mg/kg BW and 40 mg/kg BW orally once a day for 7, 14 and 21 days. Blood parameter tests were carried out on days 8, 15 and 22. Data were analyzed by two-way Analysis of Variance (ANOVA). The results showed that variations in dosage (10 mg/kg BW, 20 mg/kg BW and 40 mg/kg BW) and duration of administration (7, 14 and 21 days) of the African leaves water fraction did not affect on blood parameters (p>0.05).

Copyright

© 2021 The Authors. Published by Atlantis Press International B.V.

Open Access

This is an open access article under the CC BY-NC license.

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TY  - CONF
AU  - Dian Ayu Juwita
AU  - Helmi Arifin
AU  - Muhammad Yasin Abdullah
AU  - Dita Permatasari
PY  - 2021
DA  - 2021/11/17
TI  - Subacute Toxicity of Water Fraction of Africa Leaves (Vernonia amygdalina Del.) on Blood Parameters in Male White Mice
BT  - Proceedings of the 2nd International Conference on Contemporary Science and Clinical Pharmacy 2021 (ICCSCP 2021)
PB  - Atlantis Press
SP  - 277
EP  - 281
SN  - 2468-5739
UR  - https://doi.org/10.2991/ahsr.k.211105.040
DO  - 10.2991/ahsr.k.211105.040
ID  - Juwita2021
ER  -