Various Chloride Salt Addition in Mesoporous Material (SBA-15) Synthesis and Potential as Carrier for Dissolution Enhancer
- DOI
- 10.2991/ahsr.k.211105.050How to use a DOI?
- Keywords
- Mesoporous material; SBA-15; atorvastatin Ca; dissolution
- Abstract
Nano pores in Santa Barbara Amorphous (SBA-15) has potential to be employed as a carrier to enhance solubility and dissolution. Addition of salt on surfactant solution enabling the SBA-15 synthesis process carried on room temperature instead of 35-50°C. Atorvastatin Ca, which belongs to Biopharmaceuticals Classification System (BCS) class II, has low solubility in water, was used as a model drug. SBA-15 was synthetized using Pluronic P123:H2O:HCl:TEOS on 0.02:166:6:1 molar proportion with addition of 6 moles of inorganic salts: NaCl, KCl, MgCl2, and CaCl2. SBA-15 was impregnated to drug solution in methanol with SBA-15:ATV proportion of 1:1 before it was evaporated. The unloaded and loaded mesoporous were characterized with DTA, pXRD, FT-IR, BET and SEM. The result showed the highest surface area achieved by MgCl2 addition as 724.227 m2/g, meanwhile the biggest pore size and pore volume achieved was by the addition of KCl as 5.411 nm and 8,948 x 10-1 cm3/g. The dissolved amount in phosphate buffer 0.05 M pH 6.8 showed the significance enhancement by 2.5 to 6-fold at 5 min in comparison with intact atorvastatin Ca. In conclusion, the properties of SBA-15 vary with the addition of different salts, and can be used to enhance the dissolution of atorvastatin Ca.
- Copyright
- © 2021 The Authors. Published by Atlantis Press International B.V.
- Open Access
- This is an open access article under the CC BY-NC license.
Cite this article
TY - CONF AU - Uswatul Hasanah AU - Saleh Wikarsa AU - Sukmadjaja Asyarie PY - 2021 DA - 2021/11/17 TI - Various Chloride Salt Addition in Mesoporous Material (SBA-15) Synthesis and Potential as Carrier for Dissolution Enhancer BT - Proceedings of the 2nd International Conference on Contemporary Science and Clinical Pharmacy 2021 (ICCSCP 2021) PB - Atlantis Press SP - 343 EP - 349 SN - 2468-5739 UR - https://doi.org/10.2991/ahsr.k.211105.050 DO - 10.2991/ahsr.k.211105.050 ID - Hasanah2021 ER -