Proceedings of the 2nd International Conference on Contemporary Science and Clinical Pharmacy 2021 (ICCSCP 2021)

Stimulant Activity of Arabica Coffee Leaves (Coffea arabica L.) and Clove Flowers (Syzygium aromaticum (L.) Merr. & L.M. Perry) Ethanol Extract Mixture in Male White Mice

Authors
Rahmad Abdillah1, *, Helmi Arifin1, Fitri Rachmaini1, Melda Guswita2
1Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy Universitas Andalas, Padang 25164, West Sumatra, Indonesia.
2School of Pharmaceutical Science (STIFARM) Padang, Padang 25176, West Sumatra, Indonesia
*Corresponding author. Email: rahmadabdillah@phar.unand.ac.id
Corresponding Author
Rahmad Abdillah
Available Online 17 November 2021.
DOI
10.2991/ahsr.k.211105.051How to use a DOI?
Keywords
Stimulant effect; Coffea Arabica; Syzygium aromaticum; Central nervous system
Abstract

Arabica coffee leaves and clove flowers are some of the plants that are used as traditional medicine. Both of these plants are known to have secondary metabolites that have stimulant activity. This study aims to determine the stimulant activity of a combination of coffee leaf extract (Coffea arabica L.) and clove flower (Syzygium aromaticum (L.) Merr. & L. M.Perry). This study used 35 male white mice divided into seven groups. Normal groups, control group caffeine 13 mg/kg BW; coffee leaf extract 400 mg/kg BW; clove flower extract 400 mg/kg BW and a combination of coffee leaf extract and clove flower 300 mg/kg BW: 100 mg/kg BW; 200 mg/kg BW: 200 mg/kg BW; 100 mg/kg BW: 300 mg/kg BW orally. All treatments to mice were carried out for 15 days. The stimulant activity was tested on days 5, 10, and 15. The parameters of the stimulant activity observed were motor and sensory activity using an Automatic hole board, endurance using Tail Suspension Test, and memory using a T-Maze. The results showed that the best stimulant activity for motor, sensory, and endurance was given by a combination of coffee leaf extract: clove flower 300 mg:100 mg (P<0.05). The best stimulant activity for memory was given by a combination of coffee leaf extract: clove flower 100 mg:300 mg (P<0.05).

Copyright
© 2021 The Authors. Published by Atlantis Press International B.V.
Open Access
This is an open access article under the CC BY-NC license.

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Volume Title
Proceedings of the 2nd International Conference on Contemporary Science and Clinical Pharmacy 2021 (ICCSCP 2021)
Series
Advances in Health Sciences Research
Publication Date
17 November 2021
ISBN
978-94-6239-450-6
ISSN
2468-5739
DOI
10.2991/ahsr.k.211105.051How to use a DOI?
Copyright
© 2021 The Authors. Published by Atlantis Press International B.V.
Open Access
This is an open access article under the CC BY-NC license.

Cite this article

TY  - CONF
AU  - Rahmad Abdillah
AU  - Helmi Arifin
AU  - Fitri Rachmaini
AU  - Melda Guswita
PY  - 2021
DA  - 2021/11/17
TI  - Stimulant Activity of Arabica Coffee Leaves (Coffea arabica L.) and Clove Flowers (Syzygium aromaticum (L.) Merr. & L.M. Perry) Ethanol Extract Mixture in Male White Mice
BT  - Proceedings of the 2nd International Conference on Contemporary Science and Clinical Pharmacy 2021 (ICCSCP 2021)
PB  - Atlantis Press
SP  - 350
EP  - 356
SN  - 2468-5739
UR  - https://doi.org/10.2991/ahsr.k.211105.051
DO  - 10.2991/ahsr.k.211105.051
ID  - Abdillah2021
ER  -