Proceedings of the 2016 5th International Conference on Civil, Architectural and Hydraulic Engineering (ICCAHE 2016)

Interaction on biomarkers in goldfish after co-exposure to 17β-estradiol and benzo(a)pyrene

Authors
Zhenhua Yan, Guanghua Lu
Corresponding Author
Zhenhua Yan
Available Online October 2016.
DOI
10.2991/iccahe-16.2016.49How to use a DOI?
Keywords
17β-estradiol; ethoxyresorufin-O-deethylase; benzo(a)pyrene; vitellogenin
Abstract

The aquatic environment is challenged with complex mixtures of pollutants, which may produce synergistic or antagonistic effects in organisms, interacting on the established biomarkers. This study focuses on the interaction on biomarker responses in male goldfish (Carassius auratus) after co-exposure to 17β-estradiol (E2) and benzo(a)pyrene (BaP). Vitellogenin (Vtg), endogenous E2 and ethoxyresorufin-O-deethylase (EROD) were examined to assess the estrogenic effect, steroidogenesis, and metabolism capacity. Exposure to E2 or BaP alone significantly induced the production of Vtg and EROD, respectively. However, these inductions were markedly depressed by the co-exposed chemical, indicative of a reciprocal inhibiting interaction on Vtg and EROD. In addition, the E2-induced steroidogenesis were also suppressed by the coexisting BaP, while the steroidogenesis were not affected by BaP alone. Therefore, our results support a reciprocal inhibiting interaction on the established biomarkers on the estrogenic effect and metabolism capacity, and a one-way inhibition on the steroidogenesis pathway in goldfish after co-exposure to E2 and BaP.

Copyright
© 2016, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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Volume Title
Proceedings of the 2016 5th International Conference on Civil, Architectural and Hydraulic Engineering (ICCAHE 2016)
Series
Advances in Engineering Research
Publication Date
October 2016
ISBN
10.2991/iccahe-16.2016.49
ISSN
2352-5401
DOI
10.2991/iccahe-16.2016.49How to use a DOI?
Copyright
© 2016, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

TY  - CONF
AU  - Zhenhua Yan
AU  - Guanghua Lu
PY  - 2016/10
DA  - 2016/10
TI  - Interaction on biomarkers in goldfish after co-exposure to 17β-estradiol and benzo(a)pyrene
BT  - Proceedings of the 2016 5th International Conference on Civil, Architectural and Hydraulic Engineering (ICCAHE 2016)
PB  - Atlantis Press
SP  - 281
EP  - 285
SN  - 2352-5401
UR  - https://doi.org/10.2991/iccahe-16.2016.49
DO  - 10.2991/iccahe-16.2016.49
ID  - Yan2016/10
ER  -