Synthesis and biological evaluation of the novel antitumor agent 3'-monosubstituted chalcone derivatives

DOI

10.2991/ic3me-15.2015.101How to use a DOI?

Keywords

Chalcone derivatives, Synthesis, Antitumor, MTT

Abstract

Seven novel 3'-mono-substituted chalcone derivatives were synthesized from 2,4-dihydroxyacetophenone in 4 steps in 18-31% overall yield. Their structures were confirmed by 1H NMR. The anticancer activity of these new target compounds (4~10) against human leukemia K562 cells were evaluated by MTT assay in vitro. This study leads to the identification of one highly active molecule, compounds 10 (IC50 = 5.60 M) against K562.

Copyright

© 2015, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Luyao Wang
AU  - Hongye Zhao
AU  - Dan Wu
AU  - Long Qin
AU  - Yuou Teng
AU  - Kui Lu
PY  - 2015/08
DA  - 2015/08
TI  - Synthesis and biological evaluation of the novel antitumor agent 3'-monosubstituted chalcone derivatives
BT  - Proceedings of the 3rd International Conference on Material, Mechanical and Manufacturing Engineering
PB  - Atlantis Press
SP  - 510
EP  - 515
SN  - 2352-5401
UR  - https://doi.org/10.2991/ic3me-15.2015.101
DO  - 10.2991/ic3me-15.2015.101
ID  - Wang2015/08
ER  -