Preparation and in Vitro Dissolution of Curcumin Tablets
- DOI
- 10.2991/ic3me-15.2015.102How to use a DOI?
- Keywords
- Curcumin; dissolution; tablets; preparation process; response surface methodology
- Abstract
Objectives: To prepare curcumin tablets, and evaluate their in vitro dissolution. Methods: Curcumin was dissolved in acetone, wet-granulation and tableting. The amount of Poloxamer 188 and Gremophor RH40 were chosen as factors, and the in vitro dissolution at 120 min was used as evaluation index. The best prescription was screened by response surface method of two factors and three levels. UV-visible spectrophotometry was used as detection methods. Results: In this study, the standard curve was in good linearity with the range of 2.5~5.0 g mL-1, r = 0.9996. The average recovery was 98.08%, RSD = 0.61%. The obtained prescription: Curcumin: Poloxamer 188: Gremophor RH40 = 1: 2.52: 0.40, the in vitro dissolution at 45 min and 120 min were 64.85% and 95.12% respectively. Dissolution of the best prescription of curcumin obtained twice higher than the raw curcumin and physical mixtures, and higher than commercial products. Conclusions:The preparation method of curcumin tablets is simple and reliable, which significantly improves the dissolution of curcumin.
- Copyright
- © 2015, the Authors. Published by Atlantis Press.
- Open Access
- This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).
Cite this article
TY - CONF AU - Yuanping Wang AU - Chuqin Yu AU - Zhixiang Gan AU - Zhongbo Xie PY - 2015/08 DA - 2015/08 TI - Preparation and in Vitro Dissolution of Curcumin Tablets BT - Proceedings of the 3rd International Conference on Material, Mechanical and Manufacturing Engineering PB - Atlantis Press SP - 516 EP - 522 SN - 2352-5401 UR - https://doi.org/10.2991/ic3me-15.2015.102 DO - 10.2991/ic3me-15.2015.102 ID - Wang2015/08 ER -