Proceedings of the 3rd International Conference on Material, Mechanical and Manufacturing Engineering

Preparation and in Vitro Dissolution of Curcumin Tablets

Authors
Yuanping Wang, Chuqin Yu, Zhixiang Gan, Zhongbo Xie
Corresponding Author
Yuanping Wang
Available Online August 2015.
DOI
10.2991/ic3me-15.2015.102How to use a DOI?
Keywords
Curcumin; dissolution; tablets; preparation process; response surface methodology
Abstract

Objectives: To prepare curcumin tablets, and evaluate their in vitro dissolution. Methods: Curcumin was dissolved in acetone, wet-granulation and tableting. The amount of Poloxamer 188 and Gremophor RH40 were chosen as factors, and the in vitro dissolution at 120 min was used as evaluation index. The best prescription was screened by response surface method of two factors and three levels. UV-visible spectrophotometry was used as detection methods. Results: In this study, the standard curve was in good linearity with the range of 2.5~5.0 g mL-1, r = 0.9996. The average recovery was 98.08%, RSD = 0.61%. The obtained prescription: Curcumin: Poloxamer 188: Gremophor RH40 = 1: 2.52: 0.40, the in vitro dissolution at 45 min and 120 min were 64.85% and 95.12% respectively. Dissolution of the best prescription of curcumin obtained twice higher than the raw curcumin and physical mixtures, and higher than commercial products. Conclusions:The preparation method of curcumin tablets is simple and reliable, which significantly improves the dissolution of curcumin.

Copyright
© 2015, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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Volume Title
Proceedings of the 3rd International Conference on Material, Mechanical and Manufacturing Engineering
Series
Advances in Engineering Research
Publication Date
August 2015
ISBN
10.2991/ic3me-15.2015.102
ISSN
2352-5401
DOI
10.2991/ic3me-15.2015.102How to use a DOI?
Copyright
© 2015, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

TY  - CONF
AU  - Yuanping Wang
AU  - Chuqin Yu
AU  - Zhixiang Gan
AU  - Zhongbo Xie
PY  - 2015/08
DA  - 2015/08
TI  - Preparation and in Vitro Dissolution of Curcumin Tablets
BT  - Proceedings of the 3rd International Conference on Material, Mechanical and Manufacturing Engineering
PB  - Atlantis Press
SP  - 516
EP  - 522
SN  - 2352-5401
UR  - https://doi.org/10.2991/ic3me-15.2015.102
DO  - 10.2991/ic3me-15.2015.102
ID  - Wang2015/08
ER  -