Proceedings of the 3rd International Conference on Material, Mechanical and Manufacturing Engineering

Synthesis and Biological Evaluation of the novel Antioxidant Agent Quercetin Derivatives

Authors
Xin Qu, Hongye Zhao, Dan Wu, Lianbo Zhao, Kui Lu, Yuou Teng
Corresponding Author
Xin Qu
Available Online August 2015.
DOI
10.2991/ic3me-15.2015.100How to use a DOI?
Keywords
Quercetin, PC-12 cells, Antioxidant Activity
Abstract

Three 3-substituted derivatives of quercetin were synthesized in 10-80% overall yields. Their structures were characterized by 1HNMR. Three target compounds (4a~4c) have not been reported before. The results showed that: pre-treated of PC-12 cells with, cell survival rate was higher than that of quercetin. In this project, the oxidative damage model of PC-12 cells was established and the antioxidant activities of three newly synthesized quercetin derivatives were evaluated. Among them, compound 4b (30 M) showed the highest antioxidant activity against H2O2. Cell viability in pre-treated with or without compound 4b (30 M) were 53.05% and 10.31%, higher than that of quercetin (47.22%).

Copyright
© 2015, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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Volume Title
Proceedings of the 3rd International Conference on Material, Mechanical and Manufacturing Engineering
Series
Advances in Engineering Research
Publication Date
August 2015
ISBN
978-94-6252-100-1
ISSN
2352-5401
DOI
10.2991/ic3me-15.2015.100How to use a DOI?
Copyright
© 2015, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

TY  - CONF
AU  - Xin Qu
AU  - Hongye Zhao
AU  - Dan Wu
AU  - Lianbo Zhao
AU  - Kui Lu
AU  - Yuou Teng
PY  - 2015/08
DA  - 2015/08
TI  - Synthesis and Biological Evaluation of the novel Antioxidant Agent Quercetin Derivatives
BT  - Proceedings of the 3rd International Conference on Material, Mechanical and Manufacturing Engineering
PB  - Atlantis Press
SP  - 505
EP  - 509
SN  - 2352-5401
UR  - https://doi.org/10.2991/ic3me-15.2015.100
DO  - 10.2991/ic3me-15.2015.100
ID  - Qu2015/08
ER  -