TATA-binding Protein (TBP) Involved in the Ecdysone Signal Pathway of Drosophila
- DOI
- 10.2991/emim-15.2015.224How to use a DOI?
- Keywords
- Drosophila; Ecdysone; TBP gene; Expression profile
- Abstract
The Drosophila TATA-box binding protein (TBP) is a general transcription factor required by all three eukaryotic nuclear RNA polymerases, it can recognize the TATA-box sequence to initiate gene transcription. TBP and other TATA binding factors are spatio-temporal control of gene expression in different tissue types or in different stages of development. However, how the TBP gene is mediated is still elusive. This study reveals that TBP expression increased at molting and metamorphosis stage, 20-hydroxyecdysone (20E) can induce TBP expression, and the silence of EcR-A and USP1 led to a reduced transcript level of TBP in S2 cells. These results indicate that the TBP gene involved in the 20E signaling transduction pathway, and it acts downstream EcR and its heterodimer USP.
- Copyright
- © 2015, the Authors. Published by Atlantis Press.
- Open Access
- This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).
Cite this article
TY - CONF AU - Gang Wang PY - 2015/04 DA - 2015/04 TI - TATA-binding Protein (TBP) Involved in the Ecdysone Signal Pathway of Drosophila BT - Proceedings of the 2015 International Conference on Education, Management, Information and Medicine PB - Atlantis Press SP - 1138 EP - 1142 SN - 2352-5428 UR - https://doi.org/10.2991/emim-15.2015.224 DO - 10.2991/emim-15.2015.224 ID - Wang2015/04 ER -