Review and Outlook of Stem Cell Transplantation for Neonatal Hypoxic- Ischemic Encephalopathy
Qiu-li WANG, Hong-yan LV, Peng-shun REN, Lian-xiang LI
Available Online May 2017.
- https://doi.org/10.2991/bbe-17.2017.56How to use a DOI?
- Neonate, Hypoxic ischemic encephalopathy, Stem cell transplantation, Nerve regeneration, Nerve repair, Tissue engineering.
- Purpose: To research the states and feasibility of stem cells for neonatal hypoxic ischemic encephalopathy (HIE). Methods: In this study, "newborn, hypoxic ischemic encephalopathy, pathogenesis, stem cell transplantation" as the key words, which are searched the papers published in CNKI database and PubMed from January 1984 to December 2016.The efficacy of stem cell for neonatal HIE in animal and clinical trials are reviewed. Resultes: There are three types of stem cells for neonatal HIE including neural stem cells, mesenchymal stem cells and umbilical cord blood mononuclear stem cells. The methods and delivery routes of stem cell transplantation include intracerebra, intrathecal, peripheral intravascular and intranasal delivery. A large number of animal experiments have shown that stem cell for neonatal HIE may promote the differentiation and proliferation of endogenous stem cells, reduce the apoptosis of damaged brain tissue and improve the neurobehavioral function of animals. Clinical trials have shown that stem cell for neurological deficits in neonates with HIE has been significantly improved. Conclusions: Stem cell transplantation for neonatal HIE is a promising method, but some problems need to be solved urgently.
- Open Access
- This is an open access article distributed under the CC BY-NC license.
Cite this article
TY - CONF AU - Qiu-li WANG AU - Hong-yan LV AU - Peng-shun REN AU - Lian-xiang LI PY - 2017/05 DA - 2017/05 TI - Review and Outlook of Stem Cell Transplantation for Neonatal Hypoxic- Ischemic Encephalopathy BT - 2nd International Conference on Biomedical and Biological Engineering 2017 (BBE 2017) PB - Atlantis Press SN - 2468-5747 UR - https://doi.org/10.2991/bbe-17.2017.56 DO - https://doi.org/10.2991/bbe-17.2017.56 ID - WANG2017/05 ER -