Improved Camptothecin Production of Camptotheca Acuminata on Hydroponic Medium Supplemented with Various Chemicals

DOI

10.2991/bbe-17.2017.55How to use a DOI?

Keywords

Organic acid, Metal ion, Camptothecin yield, Hydroponic culture.

Abstract

A Hydroponic culture was conducted to determine the effect of organic acids and metal ions on plant growth, camptothecin concentrations and yield of Camptotheca acuminata, in an effort to increase the camptothecin yield by artificial cultivation. For maximal camptothecin production, increase of maleic acid to 1æmol/L, malic acid to 0.5æmol/L or malonic acid to 5æmol/L on Hoagland nutrition solution medium resulted in 1.418, 2.371 and 1.535 fold increase of camptothecin production, respectively, and increase of metal ions both La3+ and Nd3+ to 5æmol/L or Ce3+ to 1æmol/L resulted in 1.832, 1.748 and 1.822 fold production of camptothecin. These preliminary results suggested that, the application of organic acids and metal ions may be a useful and feasible method to increase camptothecin production in Camptotheca acuminata. Further research in optimizing the culture conditions of Camptotheca acuminata might permit their application for the production of camptothecin.

Copyright

© 2017, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Qing-qian ZENG
AU  - Lin JIANG
AU  - Long-ping ZHU
AU  - Hai ZHENG
AU  - De-po YANG
PY  - 2017/05
DA  - 2017/05
TI  - Improved Camptothecin Production of Camptotheca Acuminata on Hydroponic Medium Supplemented with Various Chemicals
BT  - Proceedings of the 2nd International Conference on Biomedical and Biological Engineering 2017 (BBE 2017)
PB  - Atlantis Press
SP  - 345
EP  - 350
SN  - 2468-5747
UR  - https://doi.org/10.2991/bbe-17.2017.55
DO  - 10.2991/bbe-17.2017.55
ID  - ZENG2017/05
ER  -