Influence of Daidzein and Daidzein Metabolites on Lifespan and Stress Resistance in Caenorhabditis Elegans

DOI

10.2991/bbe-16.2016.39How to use a DOI?

Keywords

Daidzein, Daidzein metabolites, C. elegans, Lifespan, Stress resistance

Abstract

Caenorhabditis elegans (C. elegans) was used as an animal model to study the influence of isoflavone daidzein and daidzein metabolites, including dihydrodaidzein (DHD), O-desmethylangolensin (O-Dma) and equol, on lifespan in C. elegans at the concentration of 0.1 mmol/L. The results showed that equol significantly increased the lifespan of C. elegans; however, O-Dma significantly shortened the lifespan of C. elegans. No obvious difference in lifespan was observed when the worms were exposed to daidzein and DHD, respectively. Further study on stress resistance demonstrated that both the thermal and oxidative stress tolerance capacity of C. elegans was significantly enhanced after being exposed to equol.

Copyright

© 2016, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Ye Wang
AU  - Xiaolei Li
AU  - Conghui Zhang
AU  - Xiuling Wang
PY  - 2016/07
DA  - 2016/07
TI  - Influence of Daidzein and Daidzein Metabolites on Lifespan and Stress Resistance in Caenorhabditis Elegans
BT  - Proceedings of the 2016 International Conference on Biomedical and Biological Engineering
PB  - Atlantis Press
SP  - 232
EP  - 237
SN  - 2468-5747
UR  - https://doi.org/10.2991/bbe-16.2016.39
DO  - 10.2991/bbe-16.2016.39
ID  - Wang2016/07
ER  -