Protective Effects of Polysaccharides from Radix Astragali Against Alloxan-induced Oxidative Stress in Diabetic Mice

DOI

10.2991/aeece-16.2016.30How to use a DOI?

Keywords

Oxidative stress; polysaccharides from Radix Astragali; alloxan; diabetic; mice.

Abstract

Oxidative stress has been proposed as an important pathogenic factor in diabetic wound complications. This study investigated the effect of polysaccharides from Radix Astragali (RAP) on alloxan-induced oxidative stress in diabetic mice. Diabetic mice were randomly divided into five groups: diabetic control, positive drug control, low, moderate, and high-dose RAP treated group. Meanwhile, normal mice were used as the control. RAP treated group received different doses of RAP (100, 200, and 400 mg/kg) via oral gavage once a day for 4 weeks. The effects of RAP on blood glucose, main antioxidant enzymes and malonaldehyde (MDA) were investigated. The results showed that RAP significantly increased superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) levels in liver and kidney, while decreasing blood glucose levels and MDA levels in liver and kidney in mice. These findings demonstrate that RAP possesses hypoglycemic and protective effect on alloxan-induced oxidative stress in diabetic mice.

Copyright

© 2016, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Ming Wu
AU  - Liquan Guo
PY  - 2016/07
DA  - 2016/07
TI  - Protective Effects of Polysaccharides from Radix Astragali Against Alloxan-induced Oxidative Stress in Diabetic Mice
BT  - Proceedings of the 2016 2nd International Conference on Advances in Energy, Environment and Chemical Engineering (AEECE 2016)
PB  - Atlantis Press
SP  - 137
EP  - 141
SN  - 2352-5401
UR  - https://doi.org/10.2991/aeece-16.2016.30
DO  - 10.2991/aeece-16.2016.30
ID  - Wu2016/07
ER  -