Volume 4, Issue 4, December 2014, Pages 228 - 232
Study on Risk Evaluation based on Occupational Exposure Evaluation and Carcinogenic Risk Simulation
Qian Zhang, Deyin Huang, Mao Liu
Received 20 August 2014, Accepted 27 October 2014, Available Online 30 December 2014.
- https://doi.org/10.2991/jrarc.2014.4.4.4How to use a DOI?
- Risk evaluation, 1,3-Butadiene, Occupational exposure evaluation, Carcinogenic risk simulation
- In order to provide the quantitative risk evaluation for 1,3-butadiene-expose, quantitative method using physiologically based pharmacokinetic model and dose-response model is applied to the carcinogenic risk evaluation for 1,3-butadiene-exposed workers. First, the internal dose of inhaled-1,3-butadiene in human beings is simulated by exposure related dose estimating model recommended by USEPA. Second, the internal dose is induced into calculating formula of carcinogenic risk. In order to determine the uncertainty of the cancer risk, Monte Carlo simulation is used to analyze the risk probability distribution. A large chemical enterprise in Tianjin is selected as the case study and carcinogenic risk evaluation for 1,3-butadiene-exposed workers is calculated. The results show that the cancer risk of 1,3-butadiene-exposed workers obviously exceeds 1×10-4 the maximum acceptable risk level. It is necessary to take relevant measures to reduce risk.
- Open Access
- This is an open access article distributed under the CC BY-NC license.
Cite this article
TY - JOUR AU - Qian Zhang AU - Deyin Huang AU - Mao Liu PY - 2014 DA - 2014/12/30 TI - Study on Risk Evaluation based on Occupational Exposure Evaluation and Carcinogenic Risk Simulation JO - Journal of Risk Analysis and Crisis Response SP - 228 EP - 232 VL - 4 IS - 4 SN - 2210-8505 UR - https://doi.org/10.2991/jrarc.2014.4.4.4 DO - https://doi.org/10.2991/jrarc.2014.4.4.4 ID - Zhang2014 ER -