Journal of Risk Analysis and Crisis Response

Volume 4, Issue 4, December 2014, Pages 228 - 232

Study on Risk Evaluation based on Occupational Exposure Evaluation and Carcinogenic Risk Simulation

Authors
Qian Zhang, Deyin Huang, Mao Liu
Corresponding Author
Qian Zhang
Received 20 August 2014, Accepted 27 October 2014, Available Online 30 December 2014.
DOI
https://doi.org/10.2991/jrarc.2014.4.4.4How to use a DOI?
Keywords
Risk evaluation, 1,3-Butadiene, Occupational exposure evaluation, Carcinogenic risk simulation
Abstract
In order to provide the quantitative risk evaluation for 1,3-butadiene-expose, quantitative method using physiologically based pharmacokinetic model and dose-response model is applied to the carcinogenic risk evaluation for 1,3-butadiene-exposed workers. First, the internal dose of inhaled-1,3-butadiene in human beings is simulated by exposure related dose estimating model recommended by USEPA. Second, the internal dose is induced into calculating formula of carcinogenic risk. In order to determine the uncertainty of the cancer risk, Monte Carlo simulation is used to analyze the risk probability distribution. A large chemical enterprise in Tianjin is selected as the case study and carcinogenic risk evaluation for 1,3-butadiene-exposed workers is calculated. The results show that the cancer risk of 1,3-butadiene-exposed workers obviously exceeds 1×10-4 the maximum acceptable risk level. It is necessary to take relevant measures to reduce risk.
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This is an open access article distributed under the CC BY-NC license.

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Journal
Journal of Risk Analysis and Crisis Response
Volume-Issue
4 - 4
Pages
228 - 232
Publication Date
2014/12/30
ISSN (Online)
2210-8505
ISSN (Print)
2210-8491
DOI
https://doi.org/10.2991/jrarc.2014.4.4.4How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - Qian Zhang
AU  - Deyin Huang
AU  - Mao Liu
PY  - 2014
DA  - 2014/12/30
TI  - Study on Risk Evaluation based on Occupational Exposure Evaluation and Carcinogenic Risk Simulation
JO  - Journal of Risk Analysis and Crisis Response
SP  - 228
EP  - 232
VL  - 4
IS  - 4
SN  - 2210-8505
UR  - https://doi.org/10.2991/jrarc.2014.4.4.4
DO  - https://doi.org/10.2991/jrarc.2014.4.4.4
ID  - Zhang2014
ER  -