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Volume 2, Issue 1, February 2021, Pages 37 - 46

Anti-Diabetic Effects of Different Phenolic-Rich Fractions from Rhus Chinensis Mill. Fruits in vitro

Authors
Xiaojing Liu, Yishan Fu, Qian Ma, Junjie Yi, Shengbao Cai*
Faculty of Agriculture and Food, Yunnan Institute of Food Safety, Kunming University of Science and Technology, Kunming, Yunnan Province 650500, People’s Republic of China
*Corresponding author. Email: caikmust2013@163.com
Corresponding Author
Shengbao Cai
Received 30 January 2021, Accepted 22 February 2021, Available Online 2 March 2021.
DOI
10.2991/efood.k.210222.002How to use a DOI?
Keywords
AGEs inhibition; Chinese sumac; DPP-IV inhibition; α-glucosidase inhibition; interaction
Abstract

This study investigated the inhibitory effects of the Ethanol Extract (EE), Free Phenolic (TF), Esterified Phenolic (TE) and Insoluble-bound Phenolic (TI) from Rhus chinensis Mill. fruits on α-glucosidase, Dipeptidyl Peptidase-4 (DPP-IV), and the formation of Advanced Glycation End (AGE) products. Results showed that the TF had the strongest inhibition against α-glucosidase and DPP-IV with IC50 of 0.56 ± 0.04 and 66.08 ± 1.36 μg/mL, respectively (p < 0.05). TI exhibited the strongest inhibitory effect on the formation of AGEs with IC50 of 0.43 ± 0.03 mg/mL (p < 0.05). Two major compounds (myricetin-3-O-rhamnoside and quercetin-3-O-rhamnoside) showed additive or synergistic effects on α-glucosidase inhibition, while displayed antagonistic effect on DPP-IV inhibition. Correlation analysis indicated that myricetin-3-O-(6″-galloyl) glycoside and myricetin O-gallate contributed significantly on α-glucosidase inhibition, while di-O-galloyl-glucoside and its isomer may contribute remarkably toward DPP-IV inhibition. Protocatechuic acid and myricetin-3-O-rhamnoside showed a positive correlation with the suppression of AGEs formation. Those results may provide some scientific information for exploring R. chinensis fruits as nutraceuticals and/or functional foods to prevent or improve diabetes.

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Copyright
© 2021 The Authors. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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<Previous Article In Issue
Next Article In Issue>
Journal
eFood
Volume-Issue
2 - 1
Pages
37 - 46
Publication Date
2021/03/02
ISSN (Online)
2666-3066
DOI
10.2991/efood.k.210222.002How to use a DOI?
Copyright
© 2021 The Authors. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

risenwbib
TY  - JOUR
AU  - Xiaojing Liu
AU  - Yishan Fu
AU  - Qian Ma
AU  - Junjie Yi
AU  - Shengbao Cai
PY  - 2021
DA  - 2021/03/02
TI  - Anti-Diabetic Effects of Different Phenolic-Rich Fractions from Rhus Chinensis Mill. Fruits in vitro
JO  - eFood
SP  - 37
EP  - 46
VL  - 2
IS  - 1
SN  - 2666-3066
UR  - https://doi.org/10.2991/efood.k.210222.002
DO  - 10.2991/efood.k.210222.002
ID  - Liu2021
ER  -