Natural Polyphenols: A Potential Therapeutic Approach to Hypoglycemia

DOI

10.2991/efood.k.200302.001How to use a DOI?

Keywords

Polyphenols; hypoglycemic; absorption; gut microbiota; microRNAs

Abstract

Natural polyphenols have been reported much attention in recent years for their hypoglycemic actions and diabetes-related pathologies. Free and simple polyphenols can be digested and absorbed in the small intestine, while complex polyphenols are utilized by intestinal flora in the large intestine. Microbial metabolites of polyphenols may regulate the production of bile acids, thus affecting the metabolism of the host. Polyphenols generally reduce postprandial blood glucose level via inhibition of α-amylase and -glucosidase and regulate glucose metabolism by inhibition of intestinal absorption of glucose and the release of glucose from the liver, stimulation of pancreatic insulin secretion, and enhancement of glucose uptake by muscle cells and adipocytes. The importance of microRNAs as regulators of anti-diabetic effects was recognized. Polyphenols can also regulate the microRNAs as therapeutic targets. This review provides a summary of the mechanisms of polyphenols on lowering blood glucose and the potential hypoglycemic in treating diabetes mellitus.

Copyright

© 2020 International Association of Dietetic Nutrition and Safety. Publishing services by Atlantis Press International B.V.

Open Access

This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - JOUR
AU  - Chao Zhao
AU  - Xuzhi Wan
AU  - Sheng Zhou
AU  - Hui Cao
PY  - 2020
DA  - 2020/03/10
TI  - Natural Polyphenols: A Potential Therapeutic Approach to Hypoglycemia
JO  - eFood
SP  - 107
EP  - 118
VL  - 1
IS  - 2
SN  - 2666-3066
UR  - https://doi.org/10.2991/efood.k.200302.001
DO  - 10.2991/efood.k.200302.001
ID  - Zhao2020
ER  -