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Volume 1, Issue 1, February 2020, Pages 38 - 52

Dietary Flavonoids in the Management of Huntington’s Disease: Mechanism and Clinical Perspective

Authors
Haroon Khan1, *, Hammad Ullah1, Rosa Tundis2, Tarun Belwal3, Hari Prasad Devkota4, Maria Daglia5, Zafer Cetin6, Eyup Ilker Saygili7, †, Maria da Graça Campos8, 9, Esra Capanoglu10, Ming Du11, Parsa Dar12, Jianbo Xiao12, *
1Department of Pharmacy, Abdul Wali Khan University, Mardan 23200, Pakistan
2Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Via P. Bucci, 87036 Rende (CS), Italy
3G.B. Pant National Institute of Himalayan Environment and Sustainable Development, Kosi-Katarmal, Almora, Uttarakhand, India
4School of Pharmacy, Kumamoto University, 5-1 Oe-honmachi, Chuo ku, Kumamoto 862-0973, Japan
5Department of Drug Science, University of Pavia, Pavia, Italy
6Department of Medical Biology and Genetic, SANKO University School of Medicine, Gaziantep, Turkey
7Department of Medical Biochemistry, SANKO University School of Medicine, Gaziantep, Turkey
8Observatory of Herb-Drug Interactions/Faculty of Pharmacy, University of Coimbra, Heath Sciences Campus, Azinhaga de Santa Comba, Coimbra, Portugal
9Coimbra Chemistry Centre (CQC, FCT Unit 313) (FCTUC), University of Coimbra, Rua Larga, Coimbra, Portugal
10Food Engineering Department, Faculty of Chemical and Metallurgical Engineering, Istanbul Technical University, Maslak 34469, Istanbul, Turkey
11School of Food Science and Technology, National Engineering Research Center of Seafood, Dalian Polytechnic University, Dalian 116034, China
12Institute of Chinese Medical Sciences, State Key Laboratory of Quality Control in Chinese Medicine, University of Macau, Avenida da Universidade, Taipa, Macau
†

Additional information: Graduate Institute of Education, Department of Molecular Medicine, SANKO University, Gaziantep, Turkey

*Corresponding authors. Email: hkdr2006@gmail.com; jianboxiao@yahoo.com
Corresponding Authors
Haroon Khan, Jianbo Xiao
Received 2 September 2019, Accepted 16 January 2020, Available Online 13 February 2020.
DOI
10.2991/efood.k.200203.001How to use a DOI?
Keywords
Anti-inflammatory; antioxidant; clinical perspective; flavonoids; Huntington’s disease; intracellular pathways
Abstract

Huntington’s disease (HD) is a neurodegenerative disorder characterized by progressive loss of neurons, which leads to behavioral systems and mental decline. HD is linked to repeat expansions of cytosine, adenine, and guanine in the Huntingtin (HTT) gene that give rise to mutation, leading to the formation of the HTT protein product. Oxidative stress also provokes the initiation and progression of HD as it leads to protein misfolding that results in the formation of inclusion which clumps together and alters neurotransmission. Despite the advancement in the field of pharmaceutical sciences, current therapeutic approaches suppress only the severity of symptoms and no therapy exists that can cure HD from its root cause. Flavonoids are the most abundant polyphenols widely present in daily dietary sources. Dietary flavonoids have a wide range of pharmacological bioactivities and many therapeutic applications. Dietary flavonoids including hesperidin, naringin, quercetin, rutin, fisetin, myricetin, luteolin, and epigallocatechin 3-O-gallate can prevent and manage HD through exerting antioxidant and anti-inflammatory activities, altering intracellular pathways, genetic alterations, and metal ion chelation. This review highlights flavonoids as therapeutic options for HD and will open new dimensions for flavonoids as safe and effective therapeutic agents in diminishing HD.

Copyright
© 2020 International Association of Dietetic Nutrition and Safety. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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Journal
eFood
Volume-Issue
1 - 1
Pages
38 - 52
Publication Date
2020/02/13
ISSN (Online)
2666-3066
DOI
10.2991/efood.k.200203.001How to use a DOI?
Copyright
© 2020 International Association of Dietetic Nutrition and Safety. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

risenwbib
TY  - JOUR
AU  - Haroon Khan
AU  - Hammad Ullah
AU  - Rosa Tundis
AU  - Tarun Belwal
AU  - Hari Prasad Devkota
AU  - Maria Daglia
AU  - Zafer Cetin
AU  - Eyup Ilker Saygili
AU  - Maria da Graça Campos
AU  - Esra Capanoglu
AU  - Ming Du
AU  - Parsa Dar
AU  - Jianbo Xiao
PY  - 2020
DA  - 2020/02/13
TI  - Dietary Flavonoids in the Management of Huntington’s Disease: Mechanism and Clinical Perspective
JO  - eFood
SP  - 38
EP  - 52
VL  - 1
IS  - 1
SN  - 2666-3066
UR  - https://doi.org/10.2991/efood.k.200203.001
DO  - 10.2991/efood.k.200203.001
ID  - Khan2020
ER  -