Idiopathic Aplastic Anemia: An Update

DOI

10.2991/chi.d.190321.002How to use a DOI?

Keywords

Acquired aplastic anemia; Bone marrow failure

Abstract

“Bone marrow failure” encompass all the conditions and syndromes in which there are qualitative or quantitative disorders of one or more lineages (erythroid, myelomonocytic, and/or megakaryocytic). A few years ago, the pathophysiology of these syndromes was completely unknown. Today we have better knowledge for these diseases, allowing the development of new treatment options and the improvement of patients' outcome. Acquired bone marrow failure syndromes include myelodysplastic syndromes, aplastic anemia, paroxysmal nocturnal hemoglobinuria, idiopathic neutropenia and large granular leukemia. All these syndromes share some common features and pathophysiology. The most important feature is the possibility of clonal evolution and progression into acute myelogenous leukemia, and open questions still remain on how to prevent evolution in these patients.

Copyright

© 2019 International Academy for Clinical Hematology. Publishing services by Atlantis Press International B.V.

Open Access

This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - JOUR
AU  - Elena E. Solomou
PY  - 2019
DA  - 2019/04/01
TI  - Idiopathic Aplastic Anemia: An Update
JO  - Clinical Hematology International
SP  - 52
EP  - 57
VL  - 1
IS  - 1
SN  - 2590-0048
UR  - https://doi.org/10.2991/chi.d.190321.002
DO  - 10.2991/chi.d.190321.002
ID  - Solomou2019
ER  -