Endothelial Dysfunction in Hematopoietic Cell Transplantation
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- 10.2991/chi.d.190317.001How to use a DOI?
- Endohtelium; Hematopoietic stem cell transplantation; Endothelial dysfunction; Inflammation; GvHD; TA-TMA
The goal of this review is to look at the role of endothelial damage and dysfunction in the initiation and development of early complications that appear after hematopoietic cell transplantation (HCT). These early complications share overlapping clinical manifestations and the suspicion of underlying endothelial damage. Several studies using different approaches, such as animal and in vitro models, the analysis of soluble biomarkers and clinical findings have provided evidence of this endothelial dysfunction. Historically, the first complication in which the role of endothelial damage was elucidated was the veno-oclusive disease/sinusoidal obstructive syndrome. In the last two decades, increasing evidence of the implication of the endothelium in the pathophysiology of other syndromes such as capillary leak syndrome, transplant-associated microangiopathy, or even graft versus host disease has accumulated. This knowledge opens up potential pharmacologic interventions to prevent/and/or treat endothelial damage and, therefore, to improve the outcome of patients receiving HCT.
- © 2019 International Academy for Clinical Hematology. Publishing services by Atlantis Press International B.V.
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- This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).
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TY - JOUR AU - Marta Palomo AU - Maribel Diaz-Ricart AU - Enric Carreras PY - 2019 DA - 2019/03/18 TI - Endothelial Dysfunction in Hematopoietic Cell Transplantation JO - Clinical Hematology International SP - 45 EP - 51 VL - 1 IS - 1 SN - 2590-0048 UR - https://doi.org/10.2991/chi.d.190317.001 DO - 10.2991/chi.d.190317.001 ID - Palomo2019 ER -