P14.05 VASCULAR AGING INDICES IN THE DISCRIMINATION OF PREMATURE CORONARY ARTERY DISEASE IN SOUTH ASIANS
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- 10.1016/j.artres.2010.10.146How to use a DOI?
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South Asian populations have a greater prevalence and earlier presentation of coronary artery disease (CAD) than populations from most other countries. The CAD risk profile common to South Asians (particularly those with early CAD) is devoid of many factors common to White populations of Western countries. Using a pilot case-control study, we assessed the effectiveness of a non-invasive approach for the discrimination of South Asians with and without premature CAD (≤55yrs) using indices of vascular aging (peripheral augmentation index (pAIX) and central BP).
Methods: CAD patients (n=27) and age-, gender-, matched healthy controls (31) were recruited at Guru Teg Bahadur (GTB) Hospital (Delhi, India). Patients and controls were assessed for (i) pAIX and central blood pressure by arterial waveform analysis using PulseCor (Aukland, New Zealand), (ii) medical history and (iii) CVD risk factors during routine outpatient clinics.
Results: Both groups were comparable for age, gender, BMI and systolic blood pressure. Smoking was more common in CAD patients (P=0.016), who were also more centrally obese (P = 0.019) than controls. Though higher amongst CAD patients, no significant difference was observed for median pAIX or central blood pressure, and other conventional CAD risk factors were comparable between groups. On multivariate logistic regression, premature CAD status was associated with history of smoking (P = 0.002), BMI (P = 0.013) and pAIX (P = 0.022).
| Risk Factors | Case (n=27) | Control (n=31) | P value |
|---|---|---|---|
| Age (years) | 44.8 (7.3) | 42.5 (7.1) | 0.227 |
| % Smoking | 70.4 (19) | 39.7 (12) | 0.016 |
| Waist to hip ratio | 0.98 (0.07) | 0.94 (0.06) | 0.019 |
| LDL to HDL ratio | 2.99 (1.43) | 2.54 (1.09) | 0.276 |
| Systolic BP (mmHg) | 122.4 (21.7) | 117.7 (10.8) | 0.314 |
| Central Sys’ BP(mmHg) | 110.0 (99.0–120.3) | 111.0 (104.7–122.0) | 0.84 |
| pAIX (%)* | 67.7 (35.0–96.7) | 52.3 (40.0–74.17) | 0.113 |
| Data are mean (SD) or *median (IQR) | |||
Discussion: Further research is warranted to investigate the utility of vascular aging indices for the stratification of CAD risk within this high-risk population.
Cite this article
TY - JOUR AU - J.V. Patel AU - P. Nikomanis AU - G. Dwivedi AU - E.A. Hughes AU - G.Y.H. Lip AU - S. Dwivedi AU - P.S. Gill PY - 2010 DA - 2010/12/02 TI - P14.05 VASCULAR AGING INDICES IN THE DISCRIMINATION OF PREMATURE CORONARY ARTERY DISEASE IN SOUTH ASIANS JO - Artery Research SP - 186 EP - 187 VL - 4 IS - 4 SN - 1876-4401 UR - https://doi.org/10.1016/j.artres.2010.10.146 DO - 10.1016/j.artres.2010.10.146 ID - Patel2010 ER -